Michał Małszycki

@malszycki.bsky.social

144 Followers 285 Following

Postdoc in the Laboratory of RNA Biology at IIMCB in Warsaw 🧬🔬 Passionate about Evolution and RNA Biology.

Graphical abstract: Speckle-proximal and speckle-dependent RNA has short introns, and simultaneous emergence of multiple exons requires heightened concentration of spliceosome components. Speckle-independent RNA has long introns and can be spliced well with or without speckles Speckle dependent introns evolved in amniotes. The reduction in intron length was accompanied by the increase of the intronic GC content, giving rise to GC-levelled intronic architecture. This exon-intron architecture is not present outside of amniotes (Fish, Invertebrates), and these organisms lack nuclear speckles.