Marty Yang @martyyang.bsky.social · Oct 11 We, in the Ramani Lab, have engineered a series of PacBio methyltransferase footprinting approaches (SAMOSA, SAMOSA-ChAAT, and SAMOSA-Tag). Now, we present Replication-Aware Single-molecule Accessibility Mapping (or RASAM, for short). (3/x)
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In brief, we have developed the experimental and computational tools needed to non-destructively and simultaneously measure replication status and protein-DNA interactions on individual chromatin fibers in vivo. (4/x)