Stephen Lu @matrixmaster.me · Jun 8

Importantly, our selection score beats strong antibody and protein LM baselines on zero-shot antibody VEP across binding and expression datasets. This suggests that learning germline-to-mature evolution adds signal beyond antibody-likeness alone. (5/8)

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Stephen Lu · Jun 8

We also explore CoSiNE as a design model. With predictor guidance sampling, we steer simulated maturation trajectories toward desired properties at inference time, biasing evolution toward antibodies with higher predicted affinity for specific antigens. (6/8)