Stephen Lu @matrixmaster.me · Jun 8 We also explore CoSiNE as a design model. With predictor guidance sampling, we steer simulated maturation trajectories toward desired properties at inference time, biasing evolution toward antibodies with higher predicted affinity for specific antigens. (6/8)
1 likes 1 replies
?
Replies
The resulting samples remain structurally plausible and human-like. We think this is a promising step toward controllable evolutionary protein design: not just generating sequences de novo, but guiding the processes that produce them. (7/8)