Michael Hoffman

@michaelhoffman.bsky.social

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Chair, Computational BIology and Medicine Program, Princess Margaret Cancer Centre, University Health Network. Associate Professor, Medical Biophysics, University of Toronto. Disclosures: https://github.com/michaelmhoffman/disclosure/

In 2025, Eddy received a letter from the National Institutes of Health, informing him that his work "had been determined to be of absolutely no value to the US taxpayer, and therefore it was being specifically terminated," he recalls.
Section 2: APPOINTMENT, SERVICE. Committee members, except those serving by virtue of holding other office, shall be appointed by the President in consultation with the Executive Committee, and may be removed by a majority vote of the Board of Directors. The President’s appointments shall, to the extent possible, reflect the diversity of the Society’s membership. The President shall designate the chairperson of each committee, also in consultation with the Executive Committee. F The Board may add or remove standing committees and may effect changes in the composition of standing committees – including the number of members and rotation schedules – by majority vote and without amendment of these Bylaws. Committees and other working groups may meet in person or by remote communication. The standing committees are:
WITH astronauts AS ( SELECT * FROM 'astronauts.parquet' QUALIFY ROW_NUMBER() OVER ( PARTITION BY name ORDER BY mission_number DESC ) = 1 ) SELECT *, year_of_selection - year_of_birth AS age, 'Age at selection' AS category FROM astronauts UNION ALL SELECT *, year_of_mission - year_of_birth AS age, 'Age at mission' AS category FROM astronauts VISUALIZE age AS x, category AS fill DRAW histogram SETTING binwidth => 1, position => 'identity' PLACE rule SETTING x => (34, 44), linetype => 'dotted' PLACE text SETTING x => (34, 44, 60), y => (66, 49, 20), label => ( 'Mean age at selection = 34', 'Mean age at mission = 44', 'John Glenn was 77\non his last mission -\nthe oldest person to\ntravel in space!' ), hjust => 'left', vjust => 'top', offset => (10, 0) SCALE fill TO accent LABEL title => 'How old are astronauts on their most recent mission?', subtitle => 'Age of astronauts when they were selected and when they were sent on their mission', x => 'Age of astronaut (years)', fill => null
When Clark was asked Thursday if he planned to allow the current budget bill to have public hearings — after it had been sitting for two weeks at the committee stage with no movement — he was cagey. "I've made no decisions," he said, a couple of hours before tabling his 1,238-word motion. The motion also seeks to schedule one day each of public hearings on a bill that overhauls school board governance and another that prevents municipalities from requiring that developments follow certain environmentally friendly standards.
Chromatin accessibility (often abbreviated or related to the concept of a11y in bioinformatics contexts, particularly when referring to open, accessible regions) refers to the degree to which nuclear DNA is accessible toDNA-binding proteins, such as transcription factors, histones, and RNA polymerase. It is a critical aspect of gene regulation, as inaccessible (compacted) chromatin restricts protein access, while open (accessible) chromatin allows for transcriptional activation
FIFA adds new even more expensive World Cup ticket categories
Project Control Peak Type Aligner Peak Caller Deduplicator Peak Count Range Difference in Called Peaks Rube No Control Broad STAR Genrich Sambamba 252158-252160 2 MACS3 Sambamba 1157876-1157882 6 Narrow STAR Genrich Sambamba 252158-252160 2 MACS3 Sambamba 1168345-1168346 1 With Control Broad STAR Genrich Sambamba 127542-127543 1 MACS3 No Deduplication 1002670-1002671 1 Sambamba 1004044-1004045 1 PePr Sambamba 568554-568556 2 Narrow STAR Genrich Sambamba 127542-127543 1 MACS3 Sambamba 1143541-1143542 1 PePr No Deduplication 1713483-1713484 1 Sambamba 721307-721309 2 BWAMEM Cisgenome Picard 15553-175097 159544 Sambamba 15553-35909 20356
Figure 2. Peak Counts for all Software Combinations. ChIP-seq data from Namani et al. 2019 and Rube et al. 2016 were run through all software combinations in Rocketchip three times each. Raw peak counts were log2 transformed and plotted in the heatmap. Darker red corresponds to higher peak counts while darker blue corresponds to lower peak counts. Gray corresponds to “NA” values, as PePr and CisGenome cannot be run without a control. The heatmap was created using R (v4.2.3) with a kernel (r-irkernel v1.3.2) in Jupyter Notebook (v1.0.0) using the following packages: ComplexHeatmap (v2.14.0), dplyr (v1.1.4), tidyr (v1.3.1), reshape2 (v1.4.4), stringr (v1.5.1), and MASS (v7.3.60.0.1).
Paid maternity/parental leave for students and postdoctoral fellows The Agencies will provide maternity/parental leave supplements within 12 months following a child’s birth or adoption to eligible students and postdoctoral fellows who are paid out of agency grants and who are the child’s primary caregivers. The supplement paid to the grant recipient will be based on the students’ and/or postdoctoral fellows’ current salary/stipend from the grant for up to 12 months to cover the leave period. The agency-paid portion of parental leave is only eligible during the grant’s authority to use funds period as it is based on the agency-funded annual salary or stipend, not on other funding sources. If both parents are supported by grant funds, each parent may take a portion of the leave for a combined maximum of 12 months. The supplement will be pro-rated if the student or postdoctoral fellow is being trained in research on a part-time basis. The administering institution is responsible for submitting a request for paid maternity/parental leave supplements to students and postdoctoral fellows by completing the Grant Amendment Form for the relevant agency’s approval.
TERFs
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The JIF– a journal-level metric– is not a measure of a specific paper or any kind of proxy or substitute metric that confers standing on an individual or institution that may have published papers in a given journal. The Journal Impact Factor should not be used irresponsibly to evaluate individual articles and researchers during research assessment.
Pelican
Briefly stated, the Gell-Mann Amnesia effect works as follows. You open the newspaper to an article on some subject you know well. In Murray's case, physics. In mine, show business. You read the article and see the journalist has absolutely no understanding of either the facts or the issues. Often, the article is so wrong it actually presents the story backward—reversing cause and effect. I call these the "wet streets cause rain" stories. Paper's full of them. In any case, you read with exasperation or amusement the multiple errors in a story—and then turn the page to national or international affairs, and read with renewed interest as if the rest of the newspaper was somehow more accurate about far-off Palestine than it was about the story you just read. You turn the page, and forget what you know. That is the Gell-Mann Amnesia effect. I'd point out it does not operate in other arenas of life. In ordinary life, if somebody consistently exaggerates or lies to you, you soon discount everything they say. In court, there is the legal doctrine of falsus in uno, falsus in omnibus, which means untruthful in one part, untruthful in all. But when it comes to the media, we believe against evidence that it is probably worth our time to read other parts of the paper. When, in fact, it almost certainly isn't. The only possible explanation for our behavior is amnesia. — Michael Crichton, "Why Speculate?" (2002)[2]
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