Manuel Irimia

@mirimiam.bsky.social

1393 Followers 659 Following

ICREA Evolutionary Biologist working on transcriptomics of development and evolution at @upf.edu and @crg.eu. Coordinator of the @evomg-bcn.bsky.social Joint Program. Lab website: http://transdevolab.com

N/C correlation vs ZGA onset improves even further adding two plant species
Regulatory conservation of MAT and ZGA gene sets
Genomic conservation of ZGA and MAT gene sets
Functional enrichments of MAT, ZGA and subsequently activated genes reflect the dynamics and needs of early development
ZGA genes share a common set of genomic features across animals
Averaged profile of expression of ZGA and MAT (maternal) gene sets
Model of N/C as a universal clock of ZGA
Strong negative correlation between log DNA size / egg volume & ZGA onset in cell cycles
No correlation between ZGA onset in hours and cycle and association with gastrulation
Distribution of ZGA onsets and attempt to reconstruct ancestral state
Landscape of ZGA onset across animals
Sampling of developmental stages across 61 animal species.
Diversity of ZGA onset in animal model organisms
Molecular adaptation in pancreatic islets associated with diet specialization: using bats to understand human diabetes
Evolution of transcriptomic susceptibilities to cancer across mammals and the evolution of cancer types
Network plot with microexon-associated phenotypes (nodes shown in dark gray). Microexon nodes are colored by exon length, and node size represents the level of conservation to the LCA as given in VastDB (109): human specific, Euarchontoglires (conserved from human to mouse and/or rat), Eutheria (to cow), Amniota (to chicken), Euteleostomi (to zebrafish), and Bilateria (to fruit fly).
Three major trends in comparative transcriptomics