Simon Mitchell @mitchell.science · Dec 6 Excited to share a new pre-print led by the incredible PhD student Aimilia Vareli. biorxiv.org/content/10.1... She asked why drugs that kill cancer cells in blood don't kill them in lymph nodes? How we can fix that? 🧵🧪 @sussexcancer.org @bsmsmedschool.bsky.social @sussexuni.bsky.social
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Diffuse Large B-cell Lymphoma (DLBCL) has lots of BCL2 and NF-kB. Both drive poor prognosis. Lots of people have tried inhibiting these. But NF-kB is 2 pathways, 5 proteins, and there are many BCL2-family proteins. We found previously (doi.org/10.3389/fonc...), each DLBCL has a unique "fingerprint".