Simon Mitchell @mitchell.science · Dec 6 Do these fingerprints predict drug responses? Yes! But what is going on with the U2932 cell line? Like lots of cancer it contains multiple cell populations with different genetics. This makes it great for figuring out how different cells in the same tumour might respond to a drug.
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We find the two cell populations in the same cell line have totally different inherent sensitivity to BCL2 inhibition! Why? One has high MCL1 to compensate for BCL2 inhibition. This is cool, but these are cells in a dish. Could we still drug these in a supportive lymph node?