Simon Mitchell @mitchell.science · Dec 6 We find the two cell populations in the same cell line have totally different inherent sensitivity to BCL2 inhibition! Why? One has high MCL1 to compensate for BCL2 inhibition. This is cool, but these are cells in a dish. Could we still drug these in a supportive lymph node?
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We used a co-culture system that mimicks how T-cells support DLBCL cells in lymph nodes. This made both cell populations resist treatment. They upregulated BCLXL which compensates for BCL2 inhibition. Inherent resistance, and micro-environmental resistance in one cell line. Neat