Simon Mitchell @mitchell.science · Dec 6 We used a co-culture system that mimicks how T-cells support DLBCL cells in lymph nodes. This made both cell populations resist treatment. They upregulated BCLXL which compensates for BCL2 inhibition. Inherent resistance, and micro-environmental resistance in one cell line. Neat
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The co-culture effect was seen in multiple cell lines, to drugs targetting BCL2 and BCLXL. This might explain why these drugs work in the lab but not in DLBCL patients. Some of this we understood: CD40 -> NIK -> RelB -> BCLXL But some really did not: CD40 -> NIK -> ? -> MCL!?