Simon Mitchell @mitchell.science · Dec 6 We knew the MCL1 was probably NF-kB's fault, isn't everything ;) We used imaging to find which NF-kB components were in the nucleus before the cells went into co-culture. Lots of RelA in cells that induce MCL1. But how does high RelA in monoculture lead to MCL1 in co-culture?
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Enter computational modelling. A model developed by Arran Pack predicted that the high RelA could create cross talk between the NF-kB pathways. CD40 -> NIK -> cRel -> MCL1? Soumen Basak has seen this before in healthy B-cells. We predict it's happening in DLBCL. Let's check