Molecular Therapy Family of Journals

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The leading family of journals in gene and cell therapy. Journals include Molecular Therapy, Advances, Nucleic Acids, and Oncology.

Holiday card with snow, evergreen tree with cells as ornaments, chromosome garland, and a snowman with Abs as hands. Text: Cell-ebrate the season! Happy holidays from the Molecular Therapy Family of Journals.
The abstract flowing waves depict the epileptic brain activity that is quieted by the adeno-associated virus (AAV) delivery of the SYNGAP1 gene. Overlaid on the waves to the left are EEG traces from an untreated Syngap1 mouse model, while the trace to the right of the AAV reflects the treated state. This highlights how the gene therapy developed by Levi and colleagues can stabilize disrupted neural signaling and restore balance to the brain. Image credit: Meagan Quinlan (concept, design, illustration) and Rong Guo (EEG traces).
On the cover: Chan, Wong, and colleagues depict how epigen improves diabetes via pancreas, liver, and adipose tissue. Image credit: Ka-Ying Chan and Zuoze Hao.
Chao and colleagues show an image of glioblastoma (red) treated with CF17 oncolytic virus (green). Image credit: Jianfei Chao.
Molecular Therapy Presents: Advancing AAV Technology October 22, 2025 | 10:00 AM CT
Direct optogenetic activation of skeletal muscle offers an alternative to invasive electrical stimulation. Knapman et al. tested the ability of adeno-associated viral vectors (AAV9 and AAVMYO) to confer light sensitivity to upper airway muscles in a model of obstructive sleep apnea. The image shows robust opsin expression (orange) in axial sections from the anterior and middle regions of a rat tongue 3 weeks after intramuscular AAV9 delivery. Image credit: Fiona L. Knapman.
Molecular Therapy podcast: Lipid nanoparticles with Drs. Daniel Stone, Harrison Dulin, and Keith R. Jerome
The cover image shows pumpkin spice DNA. Formulation is a key component in the success of nucleic acid delivery. Sallah et al. investigated how the addition of cucurbit[n]urils (CBs) to cationic polymers altered the profile of DNA delivery, reducing inflammation but increasing expression. Image credit: John Tregoning, Charlotte Tregoning, and Sophie Tregoning.
New issue of Molecular Therapy out now!
25 years of Molecular Therapy with Drs. Rayne Rouce and Joseph Glorioso
Molecular Therapy Presents: Advancements in Pediatric Cancer Therapy. Wednesday, August 6, 2025 at 1 PM CT.
Child's drawing of cancer therapies and cancer cells surrounding a heart containing a gold ribbon, the international symbol for childhood cancer awareness.
Yang et al. demonstrated that following acute kidney injury (AKI), CD38hi macrophages, derived from resident macrophages via Csf1 signaling, secrete the NAD-depleting enzyme CD38, inducing senescence in renal tubular cells and promoting chronic inflammation and renal fibrosis. The image depicts CD38hi macrophages (symbolized by wood-consuming termites) inducing tubular cell senescence (represented as tree withering) through metabolic depletion of NAD+ pools (metaphorized as essential tree nutrients). Image credit: Weijian Yao.
The American Society of Gene & Cell Therapy logo
The cover image depicts bispecific antibodies tethering mRNA-containing lipid nanoparticles (LNPs) to surface proteins on cells.
A DNA double helix in a capsule surrounded by cells. Credit: Vink Fan/Shutterstock.
Molecular Therapy Nucleic Acids welcome your submissions of original research articles and reviews.
Molecular Therapy Oncology welcomes your submissions of original research articles and reviews.
Molecular Therapy Presents: 25th Anniversary Special Issue. Wednesday, April 23, 2025 at 11 AM CT
Drs. Aysegül Yildiz and Tim Beissert join #MTNA's Editor-in-Chief Paloma Giangrande to discuss their recent MTNA article.