Ciarán Murphy-Royal

@murphyroyallab.org

2045 Followers 940 Following

Glia-neuron interactions - Astrocytes, Synapses, Behaviour, & Stress Principal Investigator, CRCHUM Associate Professor Dept. Neuroscience Université de Montréal www.murphyroyallab.org

Marie-Jo !
Picture from the 12th floor of the CRCHUM with views of Jacques Cartier bridge, Viger Square etc
Thomas introducing Michelle Olsen
Group photo left to right - Derek Bowie, Ciaran Murphy-Royal, Shannon Miedema, Jarrad Perron, Tamara Franklin
The lab! Including most of the authors involved. Left to Right = Lewis Depaauw-Holt, Kathleen Ngo, Ciaran Murphy-Royal, Marie-Josette de Medeiros, Manon Duquenne, Anthony Bosson, Clara Ireland, Camila Cabarcas Arrieta, Ossama Ghenissa, Mathias Guayasamin
two bar charts, one on the left showing reduced astrocyte calcium activity in different compartments of the EPM. On the right, behavioural change evidenced by less time spent in the closed arm, more time in the centre and open arms, indicative of reduced anxiety levels.
Bar chart showing astrocytes that were activated, inhibited, or non-responders to each neurotransmitter
Kymographs of astrocyte calcium activity evoked by several neurotransmitters
two panels from the paper. Panel C shows that activation of Gq-DREADDs in astrocytes enhances calcium activity, and Panel D shows behavioural change with more time spent in closed arms and less in centre and open arms of the EPM
Heat map of calcium activity in the EPM for neurons (top) and astrocytes (bottom) with astrocytes showing greater activity in open arms compared to closed arms.
Left - heat map of BLA astrocyte calcium activity in the elevated plus maze. Right - representative trace of BLA astrocyte activity during exploration of the elevated plus maze
Classroom with tables organized in a semi circle. Students preparing for their presentations.
Ken on stage presenting astrocyte-synapse interactions.
Fluorescence image showing astrocytes labelled with eGFP (green), what appears to be primary blood vessels with GFAP (magenta), and cell nuclei stained with DAPI (cyan)
Screenshot of email that says “new preprint finds that in the basolateral amygdala, "astrocytic activity provides a stable and scalable representation of threat-induced anxiety across an array of behavioral tasks."
Mathias giving his presentation in an amphitheatre
Snowy view from the lab
Seminar room with Charles Bourque introducing keynote speaker Quentin Pittman
Picture of a group of scientists
Various doughnuts from Homer’s!
Astrocyte expressing eGFP in green showing great morphology of an individual cell. GFAP staining in magenta labelling a blood vessel beside the green astrocyte
Snowy street scene in Montreal, at the end of March.
Poster showing details for seminar from Dr Jun Nagai. Principal Investigator Team Leader at RIKEN Centre for Brain Science Tokyo, Japan Title: Behaviorally relevant astrocyte ensembles for systems stabilization Le conférence seront présentées en anglais Le mercredi 2 Avril 2025 - Wednesday 2nd April 2025 at 12pm Locale : R05.212B
Picture of people enjoying themselves on a tropical beach
Snowy street in Montreal during a blizzard. Church spires can be see through the snow.
Two-photon image showing astrocytes with stained with SR101 in magenta, membrane tethered-GCaMP in cyan
eLife Assessment This important article explores the impact of early-life stress (ELS) on adult brain and behaviour. The significance of the convincing findings is that they implicate regulation of non-neuronal cells in the development of brain and behavioural dysfunction associated with ELS. With an elegant combination of behavioural models, morphological and functional assessments using immunostaining, electrophysiology, and viral-mediated loss-of-function approaches, the authors report that astrocyte dysfunction plays a role in ELS responses. The work is of interest to a broad behavioural and cellular neuroscience audience.
Photo of a public area covered in snow, former train station (gare Viger) and the Jacques Cartier bridge in the distance.
Time-series image showing spontaneous calcium activity in astrocytes. Arguably the most important brain cell…
Group of scientists sitting at a table