Nature Cardiovascular Research

@natcardiovascres.nature.com

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Online-only Nature Research journal that publishes basic, translational, clinical and public health research in cardiac, vascular and blood biology. https://www.nature.com/natcardiovascres/

Image: Yuka Morikawa at The Texas Heart Institute at Baylor College of Medicine. Cover design: Francesca Corra Microvascular senescence in single ventricle disease Image shows IL6 expression in samples from individuals with hypoplastic left heart syndrome. Red denotes IL6; purple denotes endothelial cells; green denotes cardiac fibroblasts; white denotes cell boundaries; and blue denotes nuclei.
Image: Jun Chen Laboratory, University of California, Los Angeles. Cover design: Bethany Vukomanovic Magnetoelastic stent for restenosis diagnosis Chen et al. describe a smart stent that combines mechanical support with continuous blood-flow sensing and demonstrate its functionality in vivo for restenosis diagnosis.
Image: Martin Dominguez, Drexel University, Irfan Kathiriya, University of California, San Francisco. Cover design: Bethany Vukomanovic TBX5 sets boundaries for a healthy heart Kathiriya et al. identify a Tbx5 + /Mef2cAHF + cardiac progenitor lineage that demarcates the interventricular septum during development, and changes in this lineage contribute to congenital heart defects in mice. (see Kathiriya et al.)
Image: Bethany Vukomanovic. Cover design: Bethany Vukomanovic Genetic insights into long COVID Human genetic analyses show that thromboembolism-related variants are associated with an increased risk of long COVID, suggesting shared pathogenic pathways and implicating the thrombin receptor PAR-1 as a potential contributor. (see Schuermans et al.)
Image: Leonardo Sacconi, Institute of Clinical Physiology. Cover design: Bethany Vukomanovic Cardiac fibrosis and arrhythmia Three-dimensional structural reconstruction of entire cleared mouse ventricles from a diseased heart acquired using mesoSPIM tomography. Myocardium is visualized by fluorescence (gray), and fibrosis is detected via scattered light (red) (see Giardini et al.).
Image: ScienceBrush Design. Cover design: Bethany Vukomanovic; RNA editing in atherosclerosis: Weldy et al. show that expression of the RNA-editing enzyme ADAR1 in smooth muscle cells regulates activation of the double-stranded RNA sensor MDA5, in a new model of atherosclerosis.
Image: Kathryn Berg. Cover design: Bethany Vukomanovic
Image: Heart and uterus image: Viarshyla Hanna / Alamy Stock Photo. Cover design: Bethany Vukomanovic
Image: Georgios Rovas, École Polytechnique Fédérale de Lausanne, 2025. Cover design: Bethany Vukomanovic
Image credit: Deqiang Kong, Yue Wang and Tianxing Yan. Cover design: Bethany Vukomanovic
Image: Atherosclerosis vessel: KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty; background: nobeastsofierce Science / Alamy Stock Photo. Cover design: Bethany Vukomanovic
A schematic illustrating the key stages and components of the overall study design.
a, UMAP of fibroblast subpopulations from different spatial positions of mouse hearts subjected to sham and MI (sham, 3 days and 28 days after infarction). n = 3 in each scRNA-seq group. b, Top marker genes expressed in each fibroblast subpopulation. c, Proportion of each fibroblast subpopulation in cardiac infarcted and remote zones at 3 days and 28 days after infarction. d, GO analysis of Cd248/Ackr3 F9 subset. e, Violin plots reflecting the Cd248 expression level in each fibroblast subpopulation (n = 15 animals). f, Violin plots reflecting the expression level of Cd248 in infarcted and remote zones at 3 days and 28 days after infarction with sham as control (n = 3 animals).