Nature Chemical Biology

@natchembio.nature.com

5117 Followers 126 Following

A scientific journal devoted to publishing the most compelling research, opinion and analysis at the intersection of chemistry and biology.

The cover image illustrates a nanobody stabilizing a formerly misfolded CFTR chloride channel, thereby enabling functional recovery
The cover image depicts the ribozyme SAMURI, which catalyzes transfer of alkyl groups from SAM to a specific adenosine in target RNA, represented as igniting a chemical spark
The cover image depicts the vulnerability of the non-transcribed strand of genes to oxidized guanines and abasic sites
The cover image with negative-stain electron microscopy grid and structure highlights the diversity of heteromeric structures of peroxiredoxin involved in redox biology
The cover depicts the neuron as a plant with the nodules surrounding the roots representing condensates of SARM1, which lead to axonal fragmentation, illustrated as fractured roots. SARM1 contains a TIR domain, also found in plants, known to form condensates that trigger NADase activity.
The cover line for the February issue is "Probing protein ensemble energies" The cover image depicts the mapping of ligand-induced changes in the E. coli Lac repressor captured by HX-MS data, used to calculate ensemble free energies of opening for proteins.
Graphical abstract on evolving synthetic intrinsically disordered proteins (synIDPs) with function
Graphical abstract on the structure and catalytic mechanism of human LPP1 variants
Graphical abstract on the unique gluing effect of ASXL1 K351 monoubiquitination enhancing deubiquitinase activity
Graphical abstract on LipoID workflow
Graphical abstract showing dinucleoside polyphosphate recognition and non-canonical transcription initiation
Graphical abstract on small molecule discovery targeting TRMT112:METTL5
Graphical abstract on the evolution of DNA polymerases to an RNA polymerase
Graphical abstract on the mechanism of action of the O-GlcNAc moiety
Graphical abstract on the photocrosslinking platform
Graphical abstract on the crosstalk between transmembrane and intracellular domains in TRPM5
Graphical abstract of the synthetic yeast toolbox
Graphical abstract depicting the mechanism of the Lamassu antiphage system
Graphical abstract showing prewetting at membranes
Graphical abstract on the DNA nanoruler platform
Graphical abstract on applications of BRET target engagement assays
Graphical abstract on cyclic imide modification by PCMT1 and recognition by CRBN, leading to protein degradation
The January cover depicts a method for real-time monitoring of microenvironmental changes in protein substructures using site-specific integration of a noncanonical amino acid with a rotor-based fluorophore
Cover image of the December issue. It depicts a diffusion-based generative deep learning pipeline for de novo design of a macrocylic peptide targeting the protein, myeloid cell leukemia 1.
The cover of the December issue. The cover depicts a SEM image of a dorsal surface of liverwort M. polymorpha female thallus. Liverwort were found to have a noncanonical pathway for the regulation of master growth repressor DELLA.
A cartoon showing how lysine acetylation within the IDR of MED1 reduces its affinity for the Pol II CTD
The October cover of Nature Chemical Biology depicting synergistic yeast consortia that mimic the collaborative interactions in plant multicellular systems, enabling the de novo biosynthesis of complex natural product lignans
The September issue cover showing translocation of synthetic condensates and DNA and RNA, facilitated by engineered DNA- and RNA-binding proteins, from the cytoplasm to the nucleus in the presence of small molecules.
Poster the 21st annual Tri-Institutional Chemical Biology Symposium.
The cover image depicts a phage-defense system TdpABC, wherein a phosphorothioate (PT) modification is made to bacterial DNA by TdpC and the invading PT-free phage DNA is degraded by the TdpAB complex
July cover featuring the UltraSelex method with the coverline - "Rapid discovery of high-affinity aptamers". The cover image depicts a target protein bound to a high-affinity aptamer that gets enriched after a single selection round with multiple elution steps.
June cover image showing an artistic depiction of a pancreas slice with spotlights on beta cells that are regenerating
The cover of the May issue with cover line "Biocomputing with trans-splicing"
Cover of the April issue featuring a scanning electron microscopy image of a cluster of methicillin-resistant Staphylococcus aureus
March cover image of Nature Chemical Biology with caption 'Sculpted by genes' on crystal biogenesis in zebrafish
February cover image of a Saponaria plant illustration
January 2025 cover
Image shows a confocal microscopy image of methylated proteins in gold in HeLa cells organizing into cytosolic puncta with a nuclear costain shown in blue.