Nature Communications

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Nature Communications is an open access journal publishing high-quality research in all areas of the biological, physical, chemical, clinical, social, and Earth sciences. www.nature.com/ncomms/

The Cross-Reactivity Dilemma: In regions where similar viruses, such as Mayaro (MAYV) and Chikungunya (CHIKV), co-circulate, standard antibody tests (ELISA or RDTs) often struggle to distinguish them. Antibodies against MAYV E2 antigen (shown as red keys) can cross-react and bind to CHIKV E2 antigen (purple key). While true, specific binding is stronger (high-scale reading), this "noisy" cross-reactive signal makes it impossible to define positive samples without more advanced methods.
The Cross-Reactivity Dilemma: In regions where similar viruses, such as Mayaro (MAYV) and Chikungunya (CHIKV), co-circulate, standard antibody tests (ELISA or RDTs) often struggle to distinguish them. Antibodies against MAYV E2 antigen (shown as red keys) can cross-react and bind to CHIKV E2 antigen (purple key). While true, specific binding is stronger (high-scale reading), this "noisy" cross-reactive signal makes it impossible to define positive samples without more advanced methods.
Colourized microscopy image of the protist Tritrichomonas foetus
Colourized microscopy image of the protist Tritrichomonas foetus
Study overview and early global spread of Omicron
Study overview and early global spread of Omicron
Proposed electron-transfer network for syntrophic acetate oxidation using granular activated carbon.
Visualization of the four types of endosymbiotic bacteria within the protist.
Visualization of the four types of endosymbiotic bacteria within the protist.
Proposed electron-transfer network for syntrophic acetate oxidation using granular activated carbon.
Visualization of the four types of endosymbiotic bacteria within the protist.
Logo for Nature Progress Oncology
Logo for Nature Progress Brain Health
Cartoon representing the mycobacterial oxidative phosphorylation system, including cytochromes, NDH-2, and ATP synthase. Taken from Figure 1 of the article.
Cartoon representing the mycobacterial oxidative phosphorylation system, including cytochromes, NDH-2, and ATP synthase. Taken from Figure 1 of the article.
Several stages of brain development in a chick embryo
Several stages of brain development in a chick embryo
We're hiring! Editor, Cell Biology & Development, Nature Communications, Springer Nature. Beijing, Shanghai or Pune. Hybrid working.
We're hiring! Editor, Cell Biology & Development, Nature Communications, Springer Nature. Beijing, Shanghai or Pune. Hybrid working.
We're hiring! Editor, Cell Biology & Development, Nature Communications, Springer Nature. Beijing, Shanghai or Pune. Hybrid working.