Nature Reviews Endocrinology

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We publish Reviews and opinion articles on all aspects of endocrinology and metabolism. https://www.nature.com/nrendo/

A schematic showing different challenges of implementing precision medicine in small island developing states and low-income and middle-income countries, as well as opportunities to facilitate precision medicine in these contexts.
A schematic showing how levels of aldosterone that are too high can affect the heart, vasculature and kidneys and contribute to cardiorenal disease.
A schematic showing how treatment with GLP1RAs can induce vasodilation and reduce inflammation.
An outline of a body showing selected organs and tissues, with zoom-ins and labels showing how they are dysregulated in polyendocrine metabolic ovarian syndrome (formerly known as polycystic ovary syndrome).
A graph-like schematic showing how resistance training and aerobic exercise before and while taking weight loss drugs can improve muscle mass, reduce adipose tissue mass and promote overall weight loss.
An image of a human body showing certain organs, with labels showing the effects of cancer cachexia.
From cover of a journal. An outline of a face in profile sits within concentric circles. The circles contain shapes and outlines of chemical structures.
Figure showing skin homeostasis and allostasis are regulated by the local neuro–immuno–endocrine system in response to environmental factors.
Figure showing the physiological effects of amylin.
Figure showing therapies targeting adrenal stem and progenitor cells to treat monogenic diseases.
Figure showing molecular mechanisms in cells of the haematopoietic lineage causal for osteoclast-poor or osteoclast-rich high bone mass.
Screenshot of a text box with five bullet points about key messages of a Review.
Figure showing a schematic representation of thyroid developmental stages.
Figure showing the potential connections between EBV and T1DM.
Screenshot of a text box titled 'Prediabetes and remission'.
Figure showing a diagnostic flow chart for secondary osteoporosis.
Front cover of Nature Reviews Endocrinology's August 2026 issue.
Screenshot of the article abstract.
Schematic diagram summarizing the effects of calorie restriction on bone health.
Figure showing how hyperinsulinaemia uncouples insulin action on different biological responses.
Figure showing mechanisms that regulate glucagon secretion.
Figure showing a summary of the weight loss differences between young and older people.
Figure showing a contextual overview of the role of hyperinsulinaemia in obesity and related conditions at the population level.
Figure showing the effects of adipose tissue-secreted factors on lymphatics and effects of lymphatic dysfunction on adipose tissue in obesity.
Figure showing trajectories of vasomotor symptoms across midlife.
KNDy neuron function during reproductive years versus menopause.
From cover of a journal. A brain (made up of interconnecting dots) sits above a cascade of random shapes in yellows and purples).
Figure showing the putative role of extracellular vesicle miRNAs in muscle-to-bone communication in ageing.
Figure showing parathyroid chief cell physiology.
Figure showing microplastic levels and polymer types reported in human tissue samples.
Figure showing sources of glucocorticoids and their effect on immune cells.
Figure showing sysregulation of insulin sensitivity, glucose uptake and pancreatic β-cell function leads to glucotoxicity and the development of diabetes mellitus-related complications.
Figures showing factors in populations at the highest risk of diabetes mellitus disparities throughout the diabetes mellitus care continuum.
Figure showing evidence on obesity biomarkers originating from adipose tissue and chronic disease risk.
Figure showing β-cell genes in congenital hyperinsulinism and their links to neurodevelopmental outcomes.
White text against a blue background, reading "The application of iPSC-derived pituitary models holds broad-ranging potential"
Figure showing the vicious cycle among cellular senescence, microbiome dysbiosis and organ ageing.
Front cover of a journal, showing a chain of paper dolls winding through a dividing cell, which is surrounded by microbiota.
Figure showing the cellular mechanism of disease in achondroplasia.
Figure showing a suggested treatment algorithm for managing bone fragility in patients with diabetes mellitus and CKD–MBD.
Figure showing the endocrine organs affected by immune-related adverse events.
Figure showing a comprehensive view of the putative functions of the adipose progenitor cells within white adipose tissue.
Figure showing that glucagon signalling in hepatocytes promotes glucose production.
Flowchart detailing the management of hypophysitis.
Figure showing tissue-specific distribution and effects of autonomic receptors on metabolic cell function.
Figure showing proposed signalling mechanisms through which paternal exercise could improve the health of offspring.
Figure showing the classification of adipokines and myokines by their specific CSF to serum ratio.
Front cover of a journal, showing outlines of people running across a stylised race track (shown as ribbons, with some twisting into a double helix shape).
Figure showing the key characteristics of metabolism-disrupting agents illustrated with specific mechanistic examples.
Figure showing pathophysiology of PCOS.
Figure showing how sex and gender interactions shape health outcomes.
Figure showing the effects of bile acids on metabolic tissues.
Figure showing a proposed model of adipogenin function.
Against a blue background, white text states "These early observations anticipated the current view that adipose tissue innervation is highly heterogeneous".
Figure showing the iceberg model of hypothyroidism.
Figure showing the mechanistic pathways mediating the relationship between insulin resistance and thyroid function and diseases.
Figure showing tubuloglomerular feedback under low thyroid hormone levels.
Figure showing the important interactive regulation of cholesterol metabolism by thyroid hormone.
Figure showing the mechanisms through which thyroid hormone controls body weight.