NC3Rs

@nc3rs.bsky.social

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A UK-based scientific organisation dedicated to helping the research community worldwide to identify, develop and use 3Rs technologies and approaches. https://nc3rs.org.uk/

Collage representing animal use and alternatives in scientific research and testing: An in vitro microphysiological system, mice being picked up using a refined tunnel handling technique, and zebrafish in an aquaculture facility.
Molecular chemical structures floating on a blue background.
A black mouse and pups in a laboratory cage with sawdust and bedding material.
Steps in the SIRF-UP (Sex Inclusive Research Framework - Understanding and Practice) process: pre-engagement survey, a support pack, apply the SIRF, post-engagement survey, stay involved.
Banner advertising the 6th session in our technology parnt3Ring webinar series on NAMs.
Wax moth larvae, Galleria mellonella, in a laboratory petri dish.
A microphysiological system and a computer programme, representing in vitro and in silico alternatives to replace animal use.
Information leaflets on the replacement, reduction and refinement of animal research, created through an NC3Rs public engagement award.
NC3Rs Technology Partn3Ring New Approach Methodologies webinar series, session 5: Wednesday 17 June, 14.00-15.15 (BST)
A rat anaesthetised following good veterinary practice, lying on a warming mat and monitored with a temperature probe.
A member of NC3Rs staff presenting at our Pint of Science public engagement event in Newcastle.
An NC3Rs-funded scientist presenting at our Pint of Science public engagement event in London.
Attendees at the NC3Rs Pint of Science public engagement event in Bristol.
Screenshot of the NC3Rs website.
A laboratory mouse being picked up in a plastic tunnel.
NC3Rs Pint of Science: Newcastle 18 May, Bristol 19 May, London 20 May. Icons representing alternative approaches to replace animals in research.
NC3Rs and iRISE train-the-trainer online workshop: Reproducibility and the Experimental Design Assistant, Wednesday 10 and 17 June, 13.00 - 16.00 (BST)
Banner shows the pint of science logo and the dates for the 2026 NC3Rs sponsored events: Newcastle 18 May, Bristol 19 May, London 20 May.
SIRF-UP, Sex Inclusive Research Framework - Understanding and Practice, from EU-SABV COST Action. Icons representing different steps of the SIRF-UP initiative: Pre-engagement survey, support pack, apply the SIRF, post-engagement survey and stay involved.
Bundles of skeletal muscle fibres representing the STRATIS CRACK IT Challenge, next to the CRACK IT logo. Text reads: Webinar recording available.
The NC3Rs Technology Partn3Ring webinar series on new approach methodologies, represented by icons of organ-on-chip, organoid, in vitro and in silico models
NC3Rs staff members typing at their laptops during a ‘I’m a scientist’ school chat session.
Bundles of skeletal muscle fibres. On the right is the CRACK IT logo. Text reads: Webinar, Thursday 5 March.
Designing better science with the NC3Rs Experimental Design Assistant (EDA).
A 'virtual dog' with interconnected nodes representing computer modelling, within the outline of a dog. On the right are the NC3Rs and VICT3R logos.
Collage of graphics representing upcoming NC3Rs online events: A virtual dog, an Experimental Design Assistant diagram, and skeletal muscle fibres.
Designing better experiments with the EDA
Delegates in discussion at a scientific meeting.
Bundles of skeletal muscle fibres next to the CRACK IT logo. Text reads: Webinar, Thursday 5 March.
An outline of a dog, the NC3Rs and VICT3R logos.
Early career researchers in discussion at a scientific training session.
Delegates in discussion at a scientific meeting.
The 3Rs Collaborative logo and an icon representing artificial intelligence 3Rs approaches. Text reads: AI survey.
Icons representing new approach methodologies in toxicology and regulatory safety assessment, including a laboratory flask, a computer model of a chemical structure and an environmental scene.
Galleria mellonella wax moth larvae in silk.
The Experimental Design Assistant (EDA) logo and the Love Methods Week logo with #LoveMethods26
A team of scientists on the BBSRC-NC3Rs ICURe Explore programme working on their commercialisation plans.
A timeline of the key phases of work that led to development of the new OCED guidance document: global survey (2021-2023), data review (2023), international workshop (2024), decision-making tool (2024), OECD Test Guidelines workplan (2024-2026).
Dr Esther Pearl, NC3Rs Programme Manager for Experimental Design, presenting about experimental rigour in animal research.
An in vitro assay. A liquid is being pipetted into a 96-well plate.
A collage of presentation slides from the LASA annual conference 3Rs session.
Alessio presents his work at Pint of Science
The transparent wing of the Drosophila fruit fly.
The latest issue of Tech3Rs is out now. Image shows a white mouse emerging from carboard tube, with shredding cardboard and a soft looking pad of materials nearby.
The welfare webinar logo alongside two photographs of animal technicians interacting with animals (pigs and beagles).
The Home Cage Analyser system set up to monitor a cage of rats.
A quote from Dr Vicky Robinson, NC3Rs Chief Executive: As always the release of the annual statistics on animal procedures presents an interesting snapshot of animal use in Great Britain. The continuing downward trend in the number of procedures is influenced by a range of factors including the efforts of the scientific community to find alternative methods, changes in scientific trends and investment decisions on where research is placed. In recent times there has been a significant uptick in efforts to replace the use of animals globally with many governments and research organisations increasing their commitments to technologies that replace the use of animals. The UK has long been at the forefront of these efforts and it is essential given the scientific, economic and societal benefits that this position is maintained. We are looking forward to the forthcoming UK government plan on alternative methods and are excited about the role that the NC3Rs can play in the delivery of this, given our expertise, networks and partnerships with key industry, academic and regulatory organisations.
Graphic showing people discussing work, the cover of the Fourth Edition of The IACUC Handbook and the chaptername: Research reproducibility and the role of the IACUC.
Anthony Holmes, NC3Rs Director of Science and Technology, chairing the Business Interaction Vouchers in-person networking event.
Illustration of CAR-T cell therapy with modified T-cells attacking a cancer cell.
A staff member performing a welfare check on mice. They are standing in front of a rack of cages and holding one cage in their hand to inspect the mice.
A brain tissue slice with cells stained and viewed under a microscope.
PhD students in an experimental design workshop at the NC3Rs-BBSRC summer school.
Report cover page: Incorporating new approach methodologies in the development of new medicines.
A black mouse with a litter of pups in a laboratory cage.
British Pharmacological Society and British Neuroscience Association logos, overlaid on an illustration of neurons. Text reads: 'Dosing in animal models of neuroscience. Time to challenge the status quo? 23 September 2025, online'.
Dr Renata Nundes receiving a poster award from the European Society for Alternatives to Animal Testing (EUSAAT) at WC13 in Rio.
Cartoon icon of a cancer cells surrounded by icons of lightbulbs, shaking hands and silhouettes.
A zebrafish is held in a hand net and swabbed.