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Welcome to the official Bluesky account for the New England Journal of Medicine. Follow for high-quality, peer-reviewed research and clinical content from the world’s leading medical journal, online at NEJM.org. Follow @ai.nejm.org for medical AI content.

An illustrated diagram from the Review Article "Antiretroviral Therapy" that shows the cycle of HIV replication and antiretroviral mechanisms of action. Blue boxes show how HIV replicates in the host CD4+ T lymphocyte through a series of steps. Red boxes show how antiretroviral drugs work by inhibiting the specific steps and enzymes of the HIV replication cycle. The NEJM identity sits at the bottom.

A graph from an Original Article published in the New England Journal of Medicine article titled "Enfortumab Vedotin and Pembrolizumab in Cisplatin-Eligible Bladder Cancer." The graph shows event-free survival. The trial name, KEYNOTE-B15/EV-304, is in parentheses after the title. The NEJM identity sits at the bottom.

A graph and chart from the correspondence
"Cardiotoxic Effects and Microdystrophin
Expression after Gene Therapy for DMD" that shows laboratory Studies and immunomodulation regimen. The top graph shows the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyltransferase, and troponin I that were serially monitored after administration of delandistrogene moxeparvovec. The bottom chart shows the immunomodulation regimen that was used to manage acute and delayed adeno-associated viral vector–associated toxic effects, along with baseline (pre–gene therapy) deflazacort (deflazacort
was discontinued at the time of vector administration when prednisone was initiated, in accordance with the gene-therapy label, and then restarted at week 14, after prednisone had been discontinued).

This image is a series of box plots showing binding antibody response at 28 days and 3 months after rVSV, rVSV Booster, and Ad26.MVA Vaccination. In Panel A, pooled rVSV Groups (N=38) and Ad26.MVA (N=17) are displayed. Panel B shows rVSV (one dose) (N=44), rVSV booster (N=25), and Ad26.MVA groups (N=55). Plots are color-coded and categorize data for different age groups, labeled as Adult and Child.

This image contains an excerpt from the Research Summary "Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus" published in the New England Journal of Medicine. It features a diagram of a patient with SLE symptoms, statistics on study participants, and illustrations of treatment groups: Obinutuzumab plus standard therapy and placebo plus standard therapy. A prompt to read the full Research Summary at NEJM.org sits at the bottom.

Upper image shows a close-up of a red, inflamed eye labeled "Episcleritis" before administration of Recombinant DNASE1L3 at 8:55 a.m. Lower image shows the same eye with reduced redness after administration of Recombinant DNASE1L3 at 4:27 p.m., 6 hours and 5 minutes later.

Bar charts illustrating overdose settings and isolation types. Panel A shows overdose deaths occurring in isolation: 72.9% in houses or apartments, 23.2% in other settings, and 4% in unknown settings. Panel B details isolation types: 70.4% had no bystander, 20.2% were spatially separated from a partner or family member, and 8.8% from other bystanders, in house or apartment settings; corresponding values in other settings were 86.3%, 2.7%, and 10.6%.

A smartphone displaying a medical case quiz from Doctordle. The screen shows a prompt for diagnosing a 62-year-old patient with chest pain and shortness of breath. The background is orange with text promoting clinical cases from NEJM on Doctordle.

A flowchart showing CDC laboratory recommendations for syphilis testing in the United States, 2024, first published in the Morbidity and Mortality Weekly Report. The flowchart appears in the NEJM Voices blog post "Syphilis Testing Is Terrible — Now Try Interpreting It" by Paul E. Sax, M.D.

This image contains an excerpt from the Research Summary "Extended Dual Antiplatelet Therapy for Multivessel Coronary Artery Disease" published in the New England Journal of Medicine. It includes data on 8,250 patients, showing an average age of 61, with 70% men and 30% women. An illustration highlights a heart with a stent implantation. The image below compares dual antiplatelet therapy (DAPT) combining Clopidogrel and aspirin, with aspirin monotherapy, each with a participant count of 4,125. A prompt to read the full Research Summary at NEJM.org sits at the bottom.

A bullet list of key points from the Clinical Practice article "Fibromyalgia" on a yellow background. The New England Journal of Medicine identity sits at the bottom.

Sunset view over the ocean from a balcony in Guam, with the sun casting a golden reflection on the water under a partly cloudy sky. A caption at the bottom left reads as follows: "The view from Guam. Image credit: Don Dizon."

A flowchart showing the workflow of expanded premarital screening program. The flowchart is broken into two columns and three rows, each shaded in a different color. The columns are labeled "Responsibility" and "General Workflow for Expanded Premarital Screening Program in Abu Dhabi." The rows are "SEHA–AHS Clinics" (shaded in light blue), "PureLab" (shaded in light yellow), and Biogenix Labs, M42 (shaded in light green).

A radiogram from the Images in Clinical Medicine article "Lead Lines in Severe Lead Poisoning." Arrows point to dense, transverse bands of metaphyseal sclerosis in the radius, ulna, metacarpals, and phalanges.

A quote from a Case Record of the Massachusetts General Hospital published in the New England Journal of Medicine reads as follows: “I will approach this case by considering infectious causes of the patient’s presentation, his immune status, the timeline of symptoms relative to his travel history, and the relevant epidemiologic factors and exposures before, during, and after travel to Madagascar.” The case record is titled "A 38-Year-Old Man with Abdominal Pain" and the authors are Aima A. Ahonkhai, M.D., M.P.H., Howard M. Heller, M.D., M.P.H., and Sarah M. Schrader, M.D., Ph.D. The background color is olive green and includes the NEJM identity.

A bullet list of key points from the Review Article "Andes Virus — A Clinical Review" on a yellow background. The New England Journal of Medicine identity sits at the bottom.

On the left is a patient with systemic lupus erythematosus. In the center are several antibody structures. To the right, a medical infusion bag is labeled "Obinutuzumab.

Two medical images from the Images in Clinical Medicine article "Descending Thoracic Aortic Aneurysm." Panel A shows a radiograph of the chest with a large, rounded opacity occupying the left hemithorax. Panel B presents CT angiography of the chest with a large, fusiform aneurysm in the descending thoracic aorta.

A medical illustration showing a heart with multivessel coronary artery disease. Nearby, there is a close-up of a drug-eluting stent. To the right, there's a calendar and two bottle representing dual antiplatelet therapy.

An infographic from the Clinical Practice article "Fibromyalgia" that shows the diagnosis and assessment of fibromyalgia. There are three sections—"ACR Diagnostic Criteria," "PROMIS-29+2," and "COPC-S"—plus an illustration of a seated patient on the right side. The NEJM identity sits at the bottom.

An illustration features a silhouette of a patient with newly diagnosed multiple myeloma, represented by red spots. To the right is a bottle labeled "Lenalidomide" and a calendar with an arrow and question mark over it. Below, two circular images show standard-risk newly diagnosed multiple myeloma and no up-front autologous stem-cell transplantation.

A table showing prevalence of health care–associated infections among all patients, 2015 vs. 2023 surveys. The first column lists type of infections, including pneumonia, gastrointestinal infections, and surgical-site infections. For each survey, there are three columns: "No. of Patients with Infection," "No. of Infections," and "Percentage of Patients with Infection." The last column shows risk difference with 95% confidence intervals.

The image is page 1 of the Public Health Alerts report "Cyfendus for Postexposure Prophylaxis after Inhalation Anthrax Exposures in Wyoming" published in NEJM Evidence in partnership with Center for Infectious Disease Research and Policy (CIDRAP) at the University of Minnesota. A slate banner at the bottom encourages readers to access the full report at evidence.nejm.org.

Cover page of NEJM.org dated July 16, 2026. It includes sections like Specialties, Topics, Multimedia, Current Issue, and Learning/CME. Featured content includes an MGH case record on a man with abdominal pain and an audio interview with Yaara Zisman-Ilani on autism and shared decision making. The page also highlights multimedia elements, such as a Quick Take video titled "Duration of Lenalidomide Therapy for Multiple Myeloma" and an Images in Clinical Medicine article titled "Descending Thoracic Aortic
Aneurysm," which contains a video.

A graph from an Original Article published in the New England Journal of Medicine article titled "Extended Dual Antiplatelet Therapy for
Multivessel Coronary Artery Disease." The graph shows major adverse cardiovascular and cerebrovascular events. The trial name, DAPT-MVD, is in parentheses after the title. The NEJM identity sits at the bottom.

A figure from an Original Article published in the New England Journal of Medicine article titled "Continuous or Fixed-Duration Maintenance Therapy in Multiple Myeloma." The figure shows Kaplan–Meier estimates of overall survival (intention-to-treat population). The trial name, ENDURANCE, is in parentheses after the title. The NEJM identity sits at the bottom.

A quote from a correspondence published in the New England Journal of Medicine reads as follows: "This outbreak highlights the reemergence of measles in the United States since its elimination in 2000." The correspondence is titled “A Regional Measles Outbreak — South Carolina, 2025–2026” and the authors are K.M. Richardson et al. The background color is dark green.

The image is a flowchart detailing the clinical course of hantavirus pulmonary syndrome. It starts with "Incubation" and "Prodrome," proceeds to "Cardiopulmonary stage" (divided into "Initial symptoms" and "ARDS and shock"), then "Early recovery," and ends with "Convalescence." Each phase lists specific symptoms and findings. Examination and laboratory findings are provided beneath the phases, describing observations and test results like physical examination outcomes and laboratory markers. An arrow at the top indicates the progression through phases.

The image is page 1 of the Public Health Alerts report "Measles Hospitalizations in Utah, 2025–2026" published in NEJM Evidence in partnership with Center for Infectious Disease Research and Policy (CIDRAP) at the University of Minnesota. A green banner at the bottom encourages readers to access the full report at evidence.nejm.org.