Ontario Institute for Cancer Research

@oicr.on.ca

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Bringing health and economic benefits to the people of Ontario through world-leading cancer research. Views expressed are those of OICR. Read the latest news from OICR at: https://oicr.on.ca/news/

20 Years of Changing Lives OICR Impact Report 2024-25
The Canadian Cancer Research Conference: New Horizons in Cancer Research: Opportunities and Challenges Abstract submissions now open.
Text on a green background that reads: "New funding opportunity"
A researcher uses a touch screen on a genome sequencing machine within the OICR genomics laboratory.
An image of patient partner Martina Wood. Below is a quote that reads: "I think a lot of people shared my incorrect assumption that clinical trials are only a last resort. But from my own cancer experience and my time as a patient partner, I’ve learned that clinical trials are offered for all stages of cancer."
A photo of Carol and below a quote: "Cancer research gave me a second chance. And I am using that opportunity to give back."
OICR research highlight Segmentation aware probabilistic phenotyping of single-cell spatial protein expression data. Segmentation errors in multiplexed imaging makeit difficult to interpret single-cell expression profiles. This is an important existing limitation for spatial biology assays as well as the development of patient biomarkers. The research team introduce evaluation metrics, a gold-standard dataset, and a probabilistic machine learning method to tackle these issues. They showed that true single-cell expression profiles may be recovered from these tissues in the absence of additional prior knowledge. Published in Nature Communications, January 2025 Authors: Dr. Kieran Campbell OICR Associate Dr. Hartland Jackson OICR Investigator