Todd Oakley @ostratodd.bsky.social · Feb 15 Not only that, but we can go the other way. We can find amino acid sites that have a strong correlation with changes in lambda-max. In the opsin world, these are called spectral tuning sites because they alter the color sensitivity of the opsin, and therefore the animal
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A common complaint about ML is it doesn't get to mechanism, just correlation. But in this case, we can mutate these amino acids and test if that affects lambda-max. In many cases (like 181 and 261 above), scientists already mutated them and they are tuning sites, so the ML is working!