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A not-for-profit open access multidisciplinary preprint platform. Research manuscripts from all fields immediately available. Supported by MDPI

Business, Economics and Management  -  Business and Management Seeing the Process Through the Worker's Eyes: Event Logs from Egocentric Factory Videos Alessandro Berti * and Wil M. P. van der Aalst
Computer Science and Mathematics  -   Artificial Intelligence and Machine Learning From Where to What: The Geo-Intervention Modelling Framework Richard Wen and Songnian Li *
Biology and Life Sciences  -   Biology and Biotechnology Endogenous Circadian Rhythms in Plant Bioelectric Signals: Cross-Station Replication and Visitor-Driven Suppression in a Public Exhibition Peter A. Gloor *
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Computer Science and Mathematics  -   Mathematics The Vertex Shift Method: Polynomial Normalization, Spectral Translation, and Dynamic Extensions Beyond the Quadratic: From Critical Points to Curved Shifts and Operator Preconditioning Sudhanshu Singh *
Biology and Life Sciences  -   Immunology and Microbiology Lipoxygenases and CFTR Inhibitory Factors Might Share the Same Role in Host-Microbe Interactions Georgy Kurakin *
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Public Health and Healthcare  -   Public, Environmental and Occupational Health Pesticide Residues in the Home—Imidacloprid Pre-Publication Executive Summary CM (Tilly) Collins *, Xindan Liang, Wanying Chen, Melanie Egli, Alexandra Richardson, Margarita White, Helena Rapp Wright, Rose Perkins and Leon Barron *
Computer Science and Mathematics  -   Artificial Intelligence and Machine Learning From Prediction to Agency: A Constrained Decision Framework and Governance Stack for Agentic AI in Clinical Diagnostics Yunguo Yu *
Biology and Life Sciences  -   Biochemistry and Molecular Biology Estrogen-Responsive Gene Modulation by Mentha pulegium L. Extract in Uterine and Ovarian Tissues of Immature Rat Lorraine Sallah *, Patrick W. Narkwa, Seth A. Domfeh, Peter N. Coffie, Patience N. Ansong, Cynthia A. Danquah, Kofi O. Owusu‐Daaku and Babatunde M. Duduyemi
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Biology and Life Sciences  -   Agricultural Science and Agronomy Volatile Compounds from Waste Shiitake Fungi Beds Enhance Rice Growth, Yield, and Performance Under High-Temperature Field Conditions Clever Nkhokwe Kanga, Rio Umezawa, Setu Rani Saha, Hideyuki Takahashi, Masanori Yamasaki and Kimiko Itoh *
Social Sciences  -   Psychology Connection to Nature in a Time of Climate Change: Emotional Responses and Mental Health Susan Clayton * and Elizabeth Marks
Preprints.org Live Q&A Schedule - July 2 — 9–11 am (CST) | 3–5 am (CEST) | 8–10 pm (CDT) - July 9 — 9–11 am (CDT) | 4–6 pm (CEST) | 10 pm–12 am (CST) - July 16 — 9–11 am (CEST) | 2–4 am (CDT) | 3–5 pm (CST) - July 23 — 9–11 am (CST) | 3–5 am (CEST) | 8–10 pm (CDT)
Welcoming Our New Screeners for June! Dr. Sk. Sarif Hassan Affiliation: Pingla Thana Mahavidyalaya, India Subject: Computer Science and Mathematics Dr. Marisa Santos Affiliation: Centro Hospitalar de Santo António; University of Porto, Portugal Subject: Medicine and Pharmacology
Environmental and Earth Sciences  -   Environmental Science Biochar as a Climate-Smart Approach for Soil Health Improvement and Nano-/Microplastic Mitigation in Sustainable Agriculture: A Review Anwar Abdelrahman Aly *
Biology and Life Sciences  -   Ecology, Evolution, Behavior and Systematics World Without Eukaryotes: Alternative Evolution of Complex Life from Giant Sulfur Bacteria Georgy Kurakin *
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Biology and Life Sciences  -   Life Sciences Effects of Salivary Amylase Gene Copy Number on Metabolic Health Sri Lakshmi Sravani Devarakonda †, Kalem Hanlon †, Alex P. Loinard-González, Bethany P. Cummings and Angela C. Poole *
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Bar chart titled “Expanding Disciplinary Diversity” comparing Preprints.org submissions across 11 subject areas in 2024 (gray) and 2025 (yellow). Biology and Life Sciences and Medicine and Pharmacology remain the largest disciplines, each exceeding 5,000 submissions in 2025. Computer Science and Mathematics shows the strongest growth, increasing from about 3,000 submissions in 2024 to about 4,500 in 2025. Physical Sciences also records notable growth, rising from roughly 1,200 to 1,900 submissions. Moderate increases are seen in Public Health and Healthcare, Social Sciences, Business, Economics and Management, and Arts and Humanities. Engineering, Environmental and Earth Sciences, and Chemistry and Materials Science remain relatively stable or show slight declines. Overall, the chart highlights continued expansion and increasing disciplinary diversity in 2025.
Medicine and Pharmacology  -   Neuroscience and Neurology Targeting Peptidylarginine Deiminases in Neurons and Astrocytes in Central Nervous System Injury—Pro-Regenerative Effects of Cl-Amidine in an Oxygen-Glucose Deprivation Model of Ischaemia (OGD/R) In Vitro Dina Ahmed, Stephen J. Getting, Maria Ashioti and Sigrun Lange *
Medicine and Pharmacology  -   Hematology Uncovering the Hidden Biology of Fibrinaloid Microclot Complexes in Complex, Inflammatory Diseases Justine M. Grixti, Etheresia Pretorius * and Douglas B. Kell *
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Computer Science and Mathematics  -   Artificial Intelligence and Machine Learning Riding AI to Utopia or Dystopia? NLP, LLM and News Informatics Insights for Artificial Intelligence Impacts on Education, Healthcare, Robotics and Careers, Changing Human Society Tanya Khanna *, Zarak Khan, Udit Goel, Jim Samuel, Julia Esguerra, Radha Jaganathan and Soumitra Bhuyan
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Engineering  -   Energy and Fuel Technology Regression-Assisted Ant Lion Optimisation of a Low-Grade-Heat Adsorption Chiller: A Decision-Support Technology for Sustainable Cooling Patricia Kwakye-Boateng, Lagouge Tartibu * and Jen Tien-Chien
Delivering fast, reliable, and responsible preprint posting 24.6 hours (Median Time to Posting) 315 Advisory Board Members (+27 in 2025) 264 Screeners Supporting Screening (+65 in 2025)
Social Sciences  -   Psychology The Evolutionary Origin of the Collective Unconscious and the Appeal of Research on Neanderthals and Other Ancient Humans Marcelo R. S. Briones *
Biology and Life Sciences  -   Agricultural Science and Agronomy From Empirical Microbial Products to Bioinputs 2.0: A Functional and Genomics-Driven Framework in Agricultural Microbiology Diego Sauka *, Carlos Piccinetti and Leopoldo Palma
Welcoming Our New Screeners for May! Prof. Dr. Antonio Aversa Affiliation: University Magna Graecia, Italy Subject: Medicine and Pharmacology Dr. Andrzej Günther Affiliation: Poznan University of Medical Sciences, Poland Subject: Chemistry and Materials Science Dr. Nurbol Tileuberdi Affiliation: Nurbol, Kazakhstan Subject: Environmental and Earth Sciences
Preprints.org Live Q&A Schedule June 2026 June 4 — 9–11 am (CEST) | 2–4 am (CDT) | 3–5 pm (CST) June 11 — 9–11 am (CDT) | 4–6 pm (CEST) | 10 pm–12 am (CST) June 18 — 9–11 am (CST) | 3–5 am (CEST) | 8–10 pm (CDT) June 25 — 9–11 am (CEST) | 2–4 am (CDT) | 3–5 pm (CST)
Medicine and Pharmacology  -   Oncology and Oncogenics Stereotactic Radiosurgery and Immunotherapy for Brain Metastases: Practical Integration, Timing, and Toxicity Rahul Barve *
Medicine and Pharmacology  -   Neuroscience and Neurology Exploratory Single-Cell RNA Sequencing of Peripheral Blood Identifies Candidate Signatures Associated with Alzheimer’s Disease Saed Sayad *, Mark Hiatt and Dhruvajyoti Roy
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Social Sciences  -   Geography, Planning and Development When All the Birds Are Singing in the Sky – Perceived Natural Sounds and Bird Diversity as Booster for Subjective Mental Health Robin Sandfort, Jelena Pavlovic and Alexandra Jiricka-Pürrer *
Public Health and Healthcare  -   Health Policy and Services Supporting Advance Care Planning Among Mandarin and Cantonese Speaking Communities: A Qualitative Exploratory Study Upma Chitkara, Ashfaq Chauhan, Ramya Walsan, Mary Li, Eric Yeung, Ursula M. Sansom-Daly and Reema Harrison
Environmental and Earth Sciences  -   Environmental Science Agricultural Expansion and Forest Transition in Mozambique: Evidence of Premature Decoupling (2001–2024) Sebastião De Hermínia Lucas Vilanculos, Sosdito Estevão Mananze and Mário Campos Cunha *
Computer Science and Mathematics  -   Artificial Intelligence and Machine Learning Smart IoT-Driven Domestic Water Quality Monitoring Systems: Architecture, Machine Learning Integration, and Implementation Challenges Tosin Comfort Olayinka *, Omoniyi James Idebi and Akinola Samson Olayinka
Business, Economics and Management  -   Business and Management Human‐Centered Governance: Reconstituting Cognitive Sovereignty in the Age of Algorithmic Systems Abdulmohsen H. Alrohaimi *
Biology and Life Sciences  -   Neuroscience and Neurology A Multi-Reward Framework to Improve Translation in Alcohol Use Disorder Cyprien G J Guerrin * and Serge H Ahmed
Welcoming Our New Screeners for April! Dr. Juan Moisés de la Serna Affiliation: Universidad Internacional de La Rioja (UNIR), Spain Subject: Medicine and Pharmacology Dr. Solomon Teferi Affiliation: Addis Ababa University, Ethiopia Subject: Engineering Dr. Alessandro Perrella Affiliation: AORN Ospedali dei Colli - P.O. D. Cotugno Regional Center for Infectious Disease, Italy Subject: Medicine and Pharmacology Dr. Marian Ion Affiliation: IMT Bucharest, Romania Subject: Engineering
Preprints.org Live Q&A Schedule May 2026 May 14: 9am CEST | 2am CDT | 3pm CST May 21: 4pm CEST | 9am CDT | 10pm CST May 28: 3am CEST | 8pm CDT | 9am CST
Public Health and Healthcare  -   Public Health and Health Services Dementia, Diabetes, and Physical Inactivity in Global Majority Populations: A Meta-Narrative Review and Recommendations Muhammad Hossain *