Putrino Lab

@putrinolab.bsky.social

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Graphical abstract of the new paper highlighting the following key concepts: • Long COVID features autoantibodies targeting neural and vascular tissues • Patients’ IgG shows increased ADCP activity against MED20 • Passive transfer of IgG induces pain and fatigue-like phenotypes in mice • Mouse pain behavior after IgG transfer correlates with patient-reported chronic pain
Image of legendary neuroscientist V. Reggie Edgerton standing in his lab with his arms folded
A picture of a very cute dog wearing a birthday hat that says the number “ten” on it
A still showing Muhammad Ali standing over an opponent with a quote: “Impossible is just a big word thrown around by small men who find it easier to live in the world they've been given than to explore the power they have to change it. Impossible is not a fact. It's an opinion. Impossible is not a declaration. It's a dare. Impossible is potential. Impossible is temporary. Impossible is nothing.”
Flyer describing our food drive and food drive needs. If you are able or interested in donating to the food drive please email ARCClinic@mountsinai.org
A bar graph showing durable effects of IMC-2 + Paxlovid beyond 600 days from the end of the protocol
A bar graph showing that IMC-2 + Paxlovid was more effective at reducing fatigue in people with LongCOVID at Day 120 than IMC-2 alone
A diagram of dolaibujg the scoring schema for the PGIC, a likert scale that scores patient-perceived improvement from 1 (no change) to 7 (a great deal better/considerable improvement)
A CONSORT diagram showing the breakdown of patients who participated in the “IMC-2 only” or “IMC-2 + Paxlovid” arms
Chart showing differences in certain Long COVID symptoms depending on gender. Some symptoms, such as disrupted sleep, occur with equal prevalence regardless of gender, whilst others, such as hair loss, are more frequent in women than men
Chart showing different variables that are predictive of a Long COVID diagnosis, including reduced morning cortisol as one of the most highly predictive factors.
Screenshot highlighting text that says “Although sub-genomic RNA was below the limit of detection, indicating low viral load, we were able to isolate and amplify infectious virus in 84.4% (27/32) of the brainstems of infected hamsters at 80 dpi”
A hand holding a copy of the book “through the shadowlands”, authored by Julie Rehmeyer