Reactome @reactome.org · Sep 4 Starting the new academic year with a Reactome Research Spotlight🖥️🧬 In the February2025 issue of Nature Communications, Carli et al. reported the development of a predictive model of cell line drug sensitivity from RNA-seq data using machine learning approaches pmc.ncbi.nlm.nih.gov/articles/PMC...
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The model leveraged Reactome pathways in combination with large language models (LLMs) to provide a mechanistic foundation. It demonstrated strong performance and was applied to predict patient drug responses, with predictions supported by experimental validation.