Rene Sugar

@renesugar.bsky.social

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https://renesugar.substack.com/

🧠 Key insight (this is the important part) What your gene set suggests is not a primary RBC disorder, but rather a “triple-hit model” affecting oxygen delivery: 1. Microvascular flow problem SERPINC1 PTGIS → capillary obstruction / dysregulation 2. Oxidative stiffening of RBCs PRDX6 → reduced deformability 3. Systemic metabolic stress DARS2, FBXL4 → worsens RBC energy + redox environment 🔬 Why this matters for ME/CFS specifically This combination maps almost perfectly onto: Reduced capillary perfusion Impaired oxygen extraction “Pseudo-hypoxia” despite normal oxygen saturation 👉 Which is exactly what many ME/CFS physiological studies show.