Leif Erik Sander 🇪🇺🇺🇦

@sanderlab.bsky.social

16886 Followers 1060 Following

Professor & Head of ID at Charité Berlin & Berlin Institute of Health German-Norwegian physician-scientist interested in Infectious diseases, respiratory medicine, vaccines & immunity, „friluftsliv“, cycling, music, democracy.

Abbildung 1A aus der Studie in Nature. Zeigt eine Kaplan-Meier Kurve mit Gesamtüberleben (Overall Survival, OS) in Prozent über die Zeit. In Rot geimpfte Patienten, in blau umgeimpfte Patienten. Man sieht ein deutlich verbessertes Gesamtüberleben. Adjustierte HR = 0.51
Hinzu kommt noch ein anderer Punkt, den die Bundesgesundheitsministerintrotz einer zunehmenden Bedrohungslage in Deutschland offenkundig nichtwahrhaben will. Müssen deutsche Soldaten in den Krieg ziehen, oder wirdDeutschland angegriffen, zählen Infektionen zu den größten Bedrohungenfür das Gesundheitswesen. So wird die Infektiologie als einzige derLeistungsgruppen in der Inneren Medizin von der Bundeswehr alswehrmedizinisch relevant eingestuft. Nun lässt sich argumentieren, dass kein Infektiologe das Krankenhausverlassen müsste, wenn die neuen Regelungen in Kraft treten. Die Medizinersind noch da, sie treten nur nicht als eigene Leistungsgruppe auf. Aber das seieine Milchmädchenrechnung, sagt Sander. „Die Leistungsgruppen habennicht nur etwas mit der Vergütung zu tun, sie legen Qualitätsstandards festund definieren, wie viel Personal mit welcher Expertise vorgehalten werdenmuss“, sagt er.
„Studien belegen, dass bis zu 20 Prozent weniger Menschen an schwerenInfektionen sterben, wenn Experten für Infektiologie die Behandlungsteuern – hier geht es um die Sicherheit und um Qualität, und nebenbei gehtes auch um erhebliche Kosten, die zusätzlich entstehen“, so Sander. „Wirgeben sehr hohe Summen für hochkomplexe Therapien wieKrebsbehandlungen, Knochenmarks- oder Organtransplantation oder fürkomplizierte chirurgische Eingriffe aus, um das Leben von Patienten zu rettenoder zu verlängern. Das sind aber genau die hochvulnerablen Patienten, die inder Folge häufig schwere Infektionen erleiden und daran versterben. Es istvollkommen kurzsichtig, genau die Expertise abzuschaffen, die für dieTherapie dieser Komplikationen so entscheidend ist. Denn genau das passiertmit der Reform.“
a,b, Comparing dementia risk (cumulative hazard, y axis) over time (x axis) after (a) exposures of female individuals to the ZVL and (b) exposure of female individuals aged 80–89 years to the RZV showed a substantial association with a decreased dementia risk at 3 and 5 years after index date compared to the PPSV23. The postmatching cohort characteristics for comparisons shown in this figure are presented in Supplementary Table 25. The curves show the Nelson–Aalen estimates of the cumulative hazard function (y axis) over the follow-up period (x axis) with a 95% CI band (shaded areas around each curve) for each cohort being compared. Cumulative hazards at specific time points are compared between the cohorts based on RR using a two-sided chi-squared statistic with 1 degree of freedom without adjusting for multiple comparisons. Superscript letter ‘a’ indicates censored, cumulative numbers of individuals who were lost to follow-up or had died until each time point; superscript letter ‘b’ indicates cumulative numbers of individuals with the event of interest (dementia diagnosis) until each time point. NMD, normalized mean difference; RR, relative risk.
Titelseite der Jubiläumsausgabe des Tagesspiegel „wie werden wir leben?“
Screenshot aus dem Referentenentwurf: "Zu Leistungsgruppe Nummer 3" Die Leistungsgruppe Infektiologie wird gestrichen.
Lecture halls during the Covipa symposium at DKFZ
A picture showing the Wannsee lake in Berlin with blue water, white sailboats and blue sky.
Zwei Abbildungen aus der zitierten Studie. links: The number of participants included in each of the analysis populations (intention-to-screen, as-screened, and per-protocol populations) are shown in the appendix (p 11). The number of eligible individuals shown in this figure differs from that in the previously published preliminary results of the COLONPREV study18 because 1245 additional participants could not be contacted after being randomly assigned because they had died before randomisation or had an inaccurate mailing address, and due to permanent exclusions among participants recruited in subsequent rounds of the study after the publication of the preliminary results. rechts: Figure 3. Kaplan Meyer Curve showing Cumulative risk of colorectal cancer at 10 years in the intention-to-screen population. No difference.
Figure 4. Relative frequencies of symptoms, hospital admissions, and healing time in days in participants with confirmed mpox among all unvaccinated and vaccinated participants in the unmatched, overall TEMVAc cohort within the observation period (vaccinated n=24, unvaccinated n=298). For healing time of pox lesions, whiskers extend from the box to the minimum and maximum values within 1·5 × IQR from Q1 and Q3, respectively. TEMVAc=Emulated Target Trial for Effectiveness of MVA-BN Vaccination Against Mpox Infection in At-risk Individuals.
left: (A) Kaplan–Meier estimates of adverse reactions for all vaccinated participants after first and second vaccination and the number of individuals at risk. Shaded areas indicate the 95% CIs for adverse reactions. (B) Relative frequencies of any local reaction or systemic reaction graded by severity as mild (not interfering with daily activities), moderate (interfering with daily activities), and severe (inability to perform daily activities) after first and second vaccination in the overall population, (C) in PLWH and PLWoH, and (D) in participants with childhood smallpox vaccination and no childhood smallpox vaccination. Severity grading was according to a modified US Food and Drug Administration scale. MVA-BN=modified vaccinia Ankara–Bavarian Nordic. PLWH=people living with HIV. PLWoH=people living without HIV. SV=childhood smallpox vaccination. (A) Dynamics of the mpox outbreak in Germany, 2022, showing the narrow time frame of overlapping MPXV infections per week (orchid coloured area, left y-axis) and the vaccination campaign (Cumulative count of first MVA-BN vaccination in Germany as violet coloured area, right y-axis). (B) Number of participants with PCR-confirmed MPXV infection per week from July 1, 2022, to Oct 31, 2022, in the vaccinated and unvaccinated groups in TEMVAc. (C) Cumulative incidence curves of PCR-confirmed MPXV infection in unvaccinated and vaccinated individuals with one dose in the overall effectiveness cohort derived as per-protocol analysis. Vertical dotted line indicates 14 days. (D) effectiveness for one dose in various subgroups ≥14 days after first vaccination. MPXV=Monkeypox virus. MVA-BN=modified vaccinia Ankara–Bavarian Nordic. PLWH=people living with HIV. PLWoH=people living without HIV. PrEP=pre-exposure prophylaxis. TEMVAc=Emulated Target Trial for Effectiveness of MVA-BN Vaccination Against Mpox Infection in At-risk Individuals.
(A) Consort diagram of SEMVAc participants included in the safety cohort. The number of second MVA-BN doses administered at or after study enrolment includes participants who received their first dose before enrolment but received the second dose during the study. Participants who remained unvaccinated or had received their vaccinations before enrolment were not part of the prospective safety cohort. (B) Consort diagram of the rolling cohort and matching of unvaccinated and vaccinated participants in the target trial TEMVAc. MVA-BN=modified vaccinia Ankara–Bavarian Nordic. SEMVAc=Safety and Effectiveness of MVA-BN Vaccination Against MPXV Infection. TEMVAc=Emulated Target Trial for Effectiveness of MVA-BN Vaccination Against Mpox Infection in At-risk Individuals.
As screenshot showing the title of the study "Safety and effectiveness of MVA-BN vaccination against mpox in at-risk individuals in Germany (SEMVAc and TEMVAc): a combined prospective and retrospective cohort study" a and two graphs illustrating the Vaccine effectiveness in the overall cohort and in sub-cohorts.
A flock of cranes flying
A screenshot showing that Pubmed.ncbi.nlm.nih.gov cannot be reached
Cover of the Economist showing Donald Trump and Vladimir Putin alone sitting at a large table with empty chairs. The title say: Europe’s worst nightmare.
Dazu der Infektiologe Prof. Dr. Leif Erik Sander, Direktor der Klinik für Infektiologie und Intensivmedizin an der Berliner Charité: „Die jüngsten gesundheitspolitischen Entwicklungen in den USA betrachten wir als infektiologische Fachgesellschaften mit großer Sorge. Neben der Pausierung lebenswichtiger medizinischer Hilfsprogramme werden wichtige Gesundheitsinformationen zensiert – darunter medizinische Leitlinien zu HIV und anderen Infektionskrankheiten, die von den Webseiten der Gesundheitsbehörde CDC entfernt wurden. Diese gravierenden staatlichen Eingriffe gefährden die medizinische Versorgung von vulnerablen Patientinnen und Patienten weltweit. Zudem greift die Regierung massiv in die Wissenschaftsfreiheit ein. Auch in Deutschland und Europa sind ähnliche autoritäre und wissenschaftsfeindliche politische Strömungen erkennbar. Vor dem Hintergrund dieser Entwicklungen und ihrer gravierenden Folgen für die öffentliche Gesundheit appellieren wir an die demokratischen Parteien, sich für den Schutz von Wissenschaft und Medizin vor Zensur und staatlichen Eingriffen einzusetzen und die internationale Zusammenarbeit in der Bekämpfung von Infektionskrankheiten zu stärken.“
Pressemitteilung der infektiologischen Fachgesellschaften zu den jüngsten Entwicklungen in der USA und ihre gravierenden Auswirkungen auf die globale Gesundheit Mein Kommentar: „Die jüngsten gesundheitspolitischen Entwicklungen in den USA betrachten wir als infektiologische Fachgesellschaften mit großer Sorge. Neben der Pausierung lebenswichtiger medizinischer Hilfsprogramme werden wichtige Gesundheitsinformationen zensiert – darunter medizinische Leitlinien zu HIV und anderen Infektionskrankheiten, die von den Webseiten der Gesundheitsbehörde CDC entfernt wurden. Diese gravierenden staatlichen Eingriffe gefährden die medizinische Versorgung von vulnerablen Patientinnen und Patienten weltweit. Zudem greift die Regierung massiv in die Wissenschaftsfreiheit ein. Auch in Deutschland und Europa sind ähnliche autoritäre und wissenschaftsfeindliche politische Strömungen erkennbar. Vor dem Hintergrund dieser Entwicklungen und ihrer gravierenden Folgen für die öffentliche Gesundheit appellieren wir an die demokratischen Parteien, sich für den Schutz von Wissenschaft und Medizin vor Zensur und staatlichen Eingriffen einzusetzen und die internationale Zusammenarbeit in der Bekämpfung von Infektionskrankheiten zu stärken.“
Screenshot from pepfair tracker website. Estimated deaths associated with the partial funding suspension from Jan 27 and present. 4,321 adult deaths 460 estimated infant deaths
Screenshot from the website of asm.org stating that the page you have tried to reach is currently under review as we evaluate the new executive orders.
Screenshot of a tweet by Elon Musk stating “USAID is a criminal organization. Time for it to die.”
Screenshot der CDC Website mit den allgemeinen Impfempfehlungen der ACIP. „Page not found“
Human H5 pseudovirus and authentic virus serum-neutralization in comparison to H5N1 infected cows. (A) Serum samples from cows experimentally infected with H5N1 (H5N1 clade 2.3.4.4b genotypes B3.13 or DE23-11-N1.3 euDG (euDG)), commercial fetal calf serum (FCS), and sera of n = 66 H5-naïve individuals were tested for neutralization activity against pseudotyped lentivirus expressing the HA of H5N1 A/Texas/37/2024. Normalized neutralization from n = 2 technical replicates is depicted by symbols with lines showing non-linear curve fits. Scatter plot shows calculated half-maximal inhibitory doses (ID50, x-fold dilution) for each of the human and bovine serum samples. (B) Sera of n = 20 H5-naïve individuals and cows experimentally infected with H5N1 were investigated by virus neutralization test (VNT100) for their neutralizing activity against authentic H5N1 euDG. *Cow data against authentic euDG was taken from Halwe et al., Nature 2024.
Detection of plasma-IgG binding and serum neutralization against A/Texas/37/2024 HA in H5-naïve individuals. (A) Study design and cohort information including sex, vaccination (vac.) status (see Table S1), and year of birth of n = 66 individuals that donated blood between August 2023 and June 2024, as well as the selected strains to test for HA binding and neutralizing activity. (B) Half-maximal effective dose (ED50)-values from plasma samples of n = 66 individuals, determined by IgG enzyme-linked immunosorbent assay (ELISA) against recombinant HA proteins derived from the strains in (A). (C) ED50-values from plasma samples of n = 66 individuals, determined by flow-cytometric measurement of IgG positive cells expressing HA proteins derived from the strains in (A) on their cell surface (see method section for details). (D) Half-maximal inhibitory dose (ID50)-values from serum samples of n = 66 individuals, determined by neutralization tests against luciferase-encoding lentivirus pseudotyped with HA variants from the strains in (A). In (B-D) the lowest tested dilution (considered as the lower limit of detection, LLOD) was a 20-fold dilution and is depicted as a dashed line in the plots. The highest tested dilution was 1:327,680. Calculated values below the LLOD were arbitrarily plotted at a constant value below the LLOD for visualization. The pairwise fold reduction in (B-D) is reported with respect to the higher geometric mean.
Cover of a commemorative issue of TIME magazine picturing the swearing in of President Barack Obama with his wife Michelle Obama in 2009.
A lake in the woods on misty day.
Impfquoten über die Zeit von 2008-2023 bei Erwachsenen mit Indikation zur Impfung gegen Influenza und Pneumokokken. Impfquoten für Influenza zwischen 30-50% und Pneumokokken 10-20%
A screenshot showing a foto of Tom Waits with a guitr sitting on a bed and the caption "happy birthday ya old stud pony. Gitty up and go!