Sandy Kilpatrick

@sandykilla.bsky.social

226 Followers 438 Following

█▓▒░░organometallics░░▒▓█ https://kilpatrickgroup.uk See also research group account: @kilpatrickgroup.bsky.social

Photo credit: Dr Amit Kumar (University of St Andrews)

Titanocene(IV)-NSAID complexes Cp2Ti(mefenamate)2 (4) and Cp2Ti(flufenamate)2 (5) show enhanced redox stability and potent cytotoxicity against breast cancer stem cells (CSCs), with 5 rivaling salinomycin and cisplatin. Complex 5 induces DNA damage and apoptosis, and its nanoparticle encapsulation improves biocompatibility. This is the first report targeting breast CSCs with titanocene-based metallodrugs.

@joedunthorne.bsky.social Children Of Radium

Prof Peter Atkins

L-R: Drs Sandy Kilpatrick, Jake Yang and Elena Piletska