Sasha Gusev @sashagusevposts.bsky.social · Nov 21 1 / 2
For nearly two decades the field has been asking why heritability estimates from molecular studies are so far below estimates from twin studies (nature.com/news/2008/08...). Are molecular studies missing important genetic variation or are twin studies biased by strong assumptions?
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Recently, multiple innovative methods have been developed to estimate "narrow-sense" heritability directly from genetic data. These methods make varying assumptions about environments and interactions, and thus allow us to triangulate on the true parameter.
Classic..this is the exact figure I use in my genetics class shifting into GWAS.