Scheff Research Lab

@schefflab.bsky.social

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The goal of our research is to investigate whether therapy targeted to peripheral neurons in the cancer microenvironment can alleviate pain and slow tumor progression. https://schefflab.pitt.edu/ #cancerneuroscience #research

Selfie of team on bicycles

Professional Development Award Recipient Poster featuring neuron in background and details for the 2026 International Cancer Neuroscience Symposium in Texas, Feb 18-20 & sponsored through MD Anderson Cancer Center and Wiley Advanced

Here is the work that got us to this point: https://jitc.bmj.com/content/12/11/e009962

Dorsal root ganglia neurons stained with green, blue, and pink dyes.

Graduate student Andre Martel Matos stands next to his poster entitled: Sympathetic Neurotransmission Contributes to Oral Cancer-Induced Spontaneous Pain.

Graduate student Andre Martel Matos presents his poster entitled "Sympathetic Neurotransmission Contributes to Oral Cancer-Induced Spontaneous Pain" to several conference attendees

Proposed cycle between nociceptive input and autonomic output in cancer. Sensitization of nociceptive sensory neurons by the tumor microenvironment leads to propagation of orthodromic signaling towards the central nervous system (CNS).