Stem Cell Evidence

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Curating the evidence in haematopoietic stem cell transplantation. Free monthly Stem Cell Evidence Alert http://bit.ly/2HMQtb5 @stemcellevidence@fediscience.org #MedSky

Image showing a PICO summary for: Letermovir prophylaxis timing in standard-risk and very high-risk adult CMV-seropositive allogeneic hematopoietic stem cell transplant recipients: A systematic literature review by Wang et al. featured in the Stem Cell Evidence Alert - June 2026
Image showing a PICO summary for: PTCy-Based versus ATG-Based GVHD Prophylaxis in Mismatched Unrelated Donor HCT: A Secondary Analysis of CIBMTR Data by Rodriguez-Rodriguez et al. featured in the Stem Cell Evidence Alert - June 2026
Image showing a PICO summary for: featured in the Stem Cell Evidence Alert - June 2026
Image showing a PICO summary for: The impact of the cryopreservation period on the CD34+ cell viability of cryopreserved cord blood units by Lee et al. featured in the Stem Cell Evidence Alert - June 2026
Image showing a PICO summary for: Cord Blood Transplantation versus Other Donor Sources in High-Risk Acute Myeloid Leukemia by Hirao et al. featured in the Stem Cell Evidence Alert - June 2026
Image showing a PICO summary for: Impact of post-transplant cyclophosphamide and anti-thymocyte globulin on immune reconstitution in MUD allo-HCT by Furnari et al. featured in the Stem Cell Evidence Alert - June 2026
Image showing a PICO summary for: A Network Meta-Analysis of Randomized Trials to Determine Optimal GVHD Prophylaxis in Matched Sibling Donor Transplantation by Bentolila et al. featured in the Stem Cell Evidence Alert - June 2026
Image showing a PICO summary for: Total body irradiation and smoking interact to increase lung cancer risk after blood or marrow transplantation by Balas et al. featured in the Stem Cell Evidence Alert - June 2026
Image showing a PICO summary for: Excellent outcomes using a novel reduced intensity conditioning with thiotepa and post-transplant cyclophosphamide for HLA-matched related donor transplant in adolescents and adults with #sicklecelldisease by Alasbali et al. featured in the Stem Cell Evidence Alert - June 2026
Image showing a PICO summary for: Addition of autologous stem-cell transplantation to an ibrutinib-containing first-line treatment in patients aged 18-65 years with mantle cell lymphoma (TRIANGLE): 4·5-year follow-up of a three-arm, randomised, open-label, phase 3 superiority trial of the European MCL Network by Dreyling et al. featured in the Stem Cell Evidence Alert - June 2026
Image showing an extract of the Stem Cell Evidence Alert - June 2026
Image showing a PICO summary for: Eculizumab for Pediatric Hematopoietic Cell Transplant-Associated Thrombotic Microangiopathy: Real-World Response Rates, Predictors of Poor Response, and an Optimal Time Point for Treatment Response Assessment by Schoettler et al. featured in the Stem Cell Evidence Alert - May 2026
Image showing a PICO summary for: Extended HLA Haplotypes and Transplant Survival by Petersdorf et al. featured in the Stem Cell Evidence Alert - May 2026
Image showing a PICO summary for: Nonmyeloablative HLA-identical sibling transplant for sickle cell disease in children: A multicenter prospective study by Nickel et al. featured in the Stem Cell Evidence Alert - May 2026
Image showing a PICO summary for: Letermovir improves the outcome of allogenic stem cell transplantation with anti-thymocyte globulin against acute leukemia and myelodysplastic syndromes by Negishi et al. featured in the Stem Cell Evidence Alert - May 2026
Image showing a PICO summary for: Haploidentical versus matched unrelated donor transplantation with post-transplant cyclophosphamide: a platform-dependent machine learning analysis of donor age by Mehta et al. featured in the Stem Cell Evidence Alert - May 2026
Image showing a PICO summary for: Safety and efficacy of ciltacabtagene autoleucel for relapsed/refractory multiple myeloma: a CIBMTR study by Hansen et al. featured in the Stem Cell Evidence Alert - May 2026
Image showing a PICO summary for: Isatuximab, carfilzomib, lenalidomide and dexamethasone in newly diagnosed multiple myeloma: a randomized phase 3 trial by Gay et al. featured in the Stem Cell Evidence Alert - May 2026
Image showing a PICO summary for: Ciprofloxacin prophylaxis in allogeneic haematopoietic cell transplantation reduces bacteraemia but increases antimicrobial resistance without improving patient outcomes by Baltas et al. featured in the Stem Cell Evidence Alert - May 2026
Image showing a PICO summary for: Maintenance Treatment With Gilteritinib Suppresses Post-transplant Relapse in Relapse/Refractory FLT3-Mutated Acute Myeloid Leukemia by Arai et al. featured in the Stem Cell Evidence Alert - May 2026
Image showing a PICO summary for: Base Editing of HBG1 and HBG2 Promoters for Sickle Cell Disease by Gupta et al. featured in the Stem Cell Evidence Alert - May 2026
Image showing an extract of the Stem Cell Evidence Alert - May 2026
Image showing a PICO summary for: Reduced relapse in high risk acute myeloid leukemia and myelodysplastic neoplasms with permissive HLA-DPB1 mismatches and post-transplant cyclophosphamide by Smallbone et al. featured in the Stem Cell Evidence Alert - April 2026
Image showing a PICO summary for: Post-transplant cyclophosphamide as graft-versus-host disease prophylaxis for matched related donor hematopoietic stem cell transplantation in acute leukemia: a systematic review and meta-analysis by Shahsavand et al. featured in the Stem Cell Evidence Alert - April 2026
Image showing a PICO summary for: Peripheral blood stem cells versus bone marrow graft for non-T-depleted haploidentical transplantation with post-transplant cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT by Nagler et al. featured in the Stem Cell Evidence Alert - April 2026
Image showing a PICO summary for: Impact of FMS-like tyrosine kinase 3 inhibitor maintenance on post-transplant outcomes in acute myeloid leukemia with FMS-like tyrosine kinase 3 mutations: a real-world German registry analysis highlighting sorafenib by Massoud et al. featured in the Stem Cell Evidence Alert - April 2026
Image showing a PICO summary for: Treatment of Acute Myeloid Leukemias and Myelodisplastic Syndromes Relapsing After Allogeneic Stem Cell Transplantation: An In-Depth Analysis of the GITMO AML/MDS-Relapse Registry Study by Malagola et al. featured in the Stem Cell Evidence Alert - April 2026
Image showing a PICO summary for: GVHD Prophylaxis With ATG and PTCy Versus PTCy-Based Regimens in Haploidentical Stem Cell Transplantation: A CTTC Study by Garcia-Horton et al. featured in the Stem Cell Evidence Alert - April 2026
Image showing a PICO summary for: Real-world outcomes for lisocabtagene maraleucel in patients with relapsed or refractory large B-cell lymphoma by Crombie et al. featured in the Stem Cell Evidence Alert - April 2026
Image showing a PICO summary for: Anti-thymocyte globulin (ATG)- or alemtuzumab-based graft-versus-host disease prophylaxis in reduced-intensity conditioning allogeneic hematopoietic cell transplantation (HCT) for patients 40 years and older with acute lymphoblastic leukemia in first complete remission: a study from the EBMT Acute Leukemia Working Party by Bug et al. featured in the Stem Cell Evidence Alert - April 2026
Image showing a PICO summary for: Restrictive versus standard hyperhydration during high-dose cyclophosphamide for hematopoietic stem cell transplantation: a retrospective cohort study by Boosman et al. featured in the Stem Cell Evidence Alert - April 2026
Image showing a PICO summary for: Randomized trial of GvHD Prophylaxis in Haploidentical PBSC Transplantation: ATG, PTCy, and Low-Dose Combination Therapy by Yang et al. featured in the Stem Cell Evidence Alert - April 2026
Image showing an extract of the Stem Cell Evidence Alert - April 2026
Image showing a PICO summary for: Who is the best allogeneic hematopoietic stem cell transplant donor for severe aplastic anemia? Data from the Chinese Bone Marrow Transplantation Registry Group (CBMTRG) by Xu et al. featured in the Stem Cell Evidence Alert - March 2026
Image showing a PICO summary for: GVHD and GRFS in patients with acute myeloid leukemia undergoing allogeneic HCT with treosulfan- versus reduced-intensity busulfan-based conditioning: a subgroup analysis of a randomized phase 3 trial by Stölzel et al. featured in the Stem Cell Evidence Alert - March 2026
Image showing a PICO summary for: Phase I/II Trials of Donor Regulatory T Cells for the Treatment of Steroid-Refractory Chronic Graft versus Host Disease by Soares et al. featured in the Stem Cell Evidence Alert - March 2026
Image showing a PICO summary for: Longitudinal Study of Late Acute and Chronic Graft-Versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation: A Long-Term Follow-up Study from the Chronic Graft-Versus-Host Disease Consortium by Pidala et al. featured in the Stem Cell Evidence Alert - March 2026
Image showing a PICO summary for: The role of HLA transcription in unrelated hematopoietic cell transplantation by Morishima et al. featured in the Stem Cell Evidence Alert - March 2026
Image showing a PICO summary for: Bone marrow transplantation for sickle cell disease using post-transplantation cyclophosphamide and 400 cGy TBI by Goldenberg et al. featured in the Stem Cell Evidence Alert - March 2026
Image showing a PICO summary for: The BIOPREVENT machine-learning algorithm predicts chronic graft-versus-host disease and mortality risk using posttransplant biomarkers by Martens et al. featured in the Stem Cell Evidence Alert - March 2026
Image showing a PICO summary for: Baseline IPSS-M vs Pretransplant Risk Downstaging as Prognostic Determinants in MDS Undergoing Allogeneic Transplantation by Aguirre et al. featured in the Stem Cell Evidence Alert - March 2026
Image showing a PICO summary for: Comparable outcomes of HSCT up-front and after failure of IST in pediatric aplastic anemia in recent years by Andresen et al. featured in the Stem Cell Evidence Alert - March 2026
Image showing a PICO summary for: HCT Frailty Scale (HCT-FS) for assessing frailty in adult candidates for allogeneic haematopoietic cell transplantation: an international prospective, observational cohort study by Salas et al. featured in the Stem Cell Evidence Alert - March 2026
Image showing an extract of the Stem Cell Evidence Alert - March 2026
Image showing a PICO summary for: GVHD prophylaxis after cord blood transplantation in patients with high-risk AML: a nationwide Japanese cohort study by Yamasaki et al. featured in the Stem Cell Evidence Alert - February 2026
Image showing a PICO summary for: Efficacy and safety of ruxolitinib for graft-versus-host disease prophylaxis in allogeneic hematopoietic stem cell transplantation: a #systematicreview and #metaanalysis by Xie e al. featured in the Stem Cell Evidence Alert - February 2026
Image showing a PICO summary for: Real-world outcomes of tisagenlecleucel treatment in patients with relapsed or refractory large B-cell lymphomas: a nationwide registry by Sakurai et al. featured in the Stem Cell Evidence Alert - February 2026
Image showing a PICO summary for: Modeling donor age and type trade-offs for personalized selection in allogeneic hematopoietic cell transplantation with post-transplant cyclophosphamide prophylaxis by Mehta et al. featured in the Stem Cell Evidence Alert - February 2026
Image showing a PICO summary for: Re-Evaluating Donor Selection Priorities for Hematopoietic Cell Transplantation With Post-Transplant Cyclophosphamide by Mehta et al. featured in the Stem Cell Evidence Alert - February 2026
Image showing a PICO summary for: Donor age and type in allogeneic haematopoietic stem cell transplantation: Strong effect in MDS, limited in AML by Kim et al. featured in the Stem Cell Evidence Alert - February 2026
Image showing a PICO summary for: Harnessing HLA Divergence for Improved Donor Selection in Haploidentical Haematopoietic Stem Cell Transplantation by Cordeiro et al. featured in the Stem Cell Evidence Alert - February 2026
Image showing a PICO summary for: RBC Alloimmunization Impacts Pediatric Sickle Cell Disease Transplant Outcomes and Transfusion Burden: A STAR Registry Report by Inam et al. featured in the Stem Cell Evidence Alert - February 2026
Image showing a PICO summary for: The impact of DNMT3A mutation on survival of AML patients receiving allotransplant in first remission depends on the karyotype and co-occurring mutations Abou Dalle et al. featured in the Stem Cell Evidence Alert - February 2026
Image showing a PICO summary for: Orca-T versus allogeneic hematopoietic stem cell transplantation (PRECISION-T): a multicenter, randomized phase 3 trial by Meyer et al. featured in the Stem Cell Evidence Alert - February 2026
Image showing an extract of the Stem Cell Evidence Alert - February 2026
Image showing a PICO summary for: Impact of donor selection in adverse-risk AML undergoing hematopoietic cell transplantation: A study from the EBMT Acute Leukemia Working Party by Villalba et al. featured in the Stem Cell Evidence Alert - January 2026
Image showing a PICO summary for: Comparison of Myeloablative Busulfan/Cyclophosphamide and Busulfan/Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation: A #SystematicReview and #Meta-Analysis by Shimada et al. featured in the Stem Cell Evidence Alert - January 2026
Image showing a PICO summary for: Model-based antithymocyte globulin dosing in ex vivo CD34+ selected allogeneic haematopoietic cell transplantation: a single-centre, single-arm, phase 2 study by Scordo et al. featured in the Stem Cell Evidence Alert - January 2026
Image showing a PICO summary for: Outcomes following matched sibling donor transplantation for severe combined immunodeficiency: a report from the PIDTC by Rayes et al. featured in the Stem Cell Evidence Alert - January 2026
Image showing a PICO summary for: Genetic Findings of Potential Donor Origin in Cells Used for Cell and Gene Therapy: Recommendations from the World Marrow Donor Association by Pryce et al. featured in the Stem Cell Evidence Alert - January 2026