David Strutt

@struttlab.bsky.social

534 Followers 403 Following

Cell and developmental biology at the University of Sheffield unravelling the mysteries of planar polarity using Drosophila

Planar polarity in the Drosophila pupal wing is oriented by tissue stress but the mechanisms remain unclear. This study uncovers a crucial role for cell flow gradients in promoting planar polarity protein turnover and aligning proximodistal polarity.
Two fields of spiky looking cells under a microscope. Left field has a few bright cells, the right field many bright cells. Left field labelled 'New Batch Effectene' the right field 'Old Batch Effectene'.
Four lateral flow tests. One positive and three negative.
Graphical abstract showing model for Fat-Dachsous cadherin interaction via a second newly identified site