Omer Dushek @tcell.bsky.social · Jan 16

We find high correlations between 3D affinities and 2D affinities, and with T cell responses. We don’t find a sharp affinity threshold but rather imperfect antigen discrimination. We show that the kinetic proofreading mechanism can explain this level of discrimination with high antigen sensitivity.

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Omer Dushek · Jan 16

Our results underline the ability of T cells to effectively gauge proxies for 3D affinity within the 2D cell-cell interface, which is predicted by a model whereby the TCR/pMHC interactions are shielded by molecular forces (e.g. Pettmann et al (2023) EMBO J; Schrangl et al (2024) bioRxiv)