Tessa Green

@tessallator.bsky.social

268 Followers 404 Following

computational immunology and transcriptomics @KiraGenBio| formerly @MIT@harvardmed and @hgsuuaw healthcare | she/her | 🏳️‍🌈👩🏻‍💻 tessadgreen.github.io

Tessa (a white girl with short brown hair and giant tortoiseshell glasses) holding a golden retriever puppy in front of an airstream
Overview of distance metric performance for each dataset and metric evaluation method, colored by rank across the evaluated metrics. The mean score for each metric is shown on the right, colored by the category each distance was assigned to (referred to as “type” below). Distances of the same type have similar absolute values. Type I distances performed better overall across tasks and datasets.
x-axis effect size (eg developmental time, dosage, or number of guides). y-axis distance. Spearman correlation 0.66. Cartoon data, conditions with larger effect size tend to have a larger distance.
x-axis rank of distance from one control subpopulation, y-axis distance. A poor performing metric has large control-control distances, and a high-performing one has consistently small control-control distances.
Circle representing cell populations: control (untreated condition in the same tissue) and perturbations (colored circles). All are subsampled to the same number of cells, with 5 subsamplings of the control. Distance in gene expression between populations of equal size is calculated using various metrics.
Predicts vs control evaluation using different distances, comparing performance of scGen default, scGen shallow, and linear regression for predicting gene expression of perturbed cells. Best performing model changes dramatically with the metric used.)
google search for symptoms of T cell exhaustion. AI overview: T cell exhaustion is a process that occurs when T cells are continulous stimulated and lose their ability to fight back. Symptoms include: Progressive loss of function: T cells lose their ability to proliferate and kill, and eventually lose the ability to produce cytokines like IL-2, TNF-alpha, and IFN-gamma Upregulation of inhibitory receptors: T cells express multiple inhibitory receptors such as PD-1, TIM-3, LAG-3 and TIGiT Altered cellular progiles: T cells have altered cellular metabolic, gene expression and epigenetic profiles. T cell exhaustion can occur during chronic viral infections, such as HIV and hepatitis, chronic non-viral infections, such as malaria, and human cancers
T cell exhaustion is "a condition where T cells, a type of immune cell, lose their ability to fight off viruses and tumors" (quote highlighted). This can happen when the body's immune system is kept active for a long time, such as during chronic infections or cancer. Symptoms: feeling sick, damage caused by T cells Causes: chornic stimulation of T cells by an antigen, such as virus or tumor Effects: T cells produce less immune response-stimulating proteins and are less able to kill virus-infected or tumor cells Treatment: Drugs that target immune checkpoint proteins on the surface of exhausted T cells may help them better kill cancer cells
Aranet4 showing 627 PPM CO2 on my desk
Dryer full of US bills and a clutch bag
Cambridge MA city council organizational affiliations displayed in a horrible approximation of a Venn diagram with a lot of excess text expanding acronyms. I’m sorry I’m not typing it all out but the main point is that even when groups overlap the names are just listed twice, and the overlaps of the circles have nothing to do with membership overlaps. A Better Cambridge is displayed as unconnected to other orgs even though their endorsed candidates are sometimes listed under CRESA or the DSA
A woman with pink hair and a purple flannel smiles next to a large fish, which seems fine looking at her. A sign underneath says “Giant Siamese Carp”
A woman in a car with brown-ish purple-ish hair wearing sunglasses, a white Oxford shirt, a black boat-style mask, and silver manifold earrings with a bright orange bead
6. Please provide all Supplementary Tables as one Excel workbook with multiple tabs if possible and update the Inventory file accordingly
Purple flowers in a glass vase. Prairie clover and snapdragons mostly.
Purple tinted brown hair
Brown hair in a messy topknot slathered in purple dye
Nonogram level completed screen. The background is blue. The image from the puzzle shows a low resolution drawing of the face of a white man with brown hair and a red hat. The image is labeled as “Jacques-Yves Cousteau”