Tim Fennell

@tfenne.bsky.social

605 Followers 147 Following

Bioinformatician, Leader, Founder @fulcrumgenomics.bsky.social https://www.fulcrumgenomics.com

Innocuous questions truly route to fable; anything even vaguely bio or infosec gets silently downgraded to Opus.
What model did a sub-agent use to generate a response?
Hex-bin density plot of per-read CpH observations vs. conversions.
m-bias curves on an example cfDNA em-seq dataset
Riker wgs is now 20-40% faster than mosdepth on 1000G data from 4x to 30x coverage.
My hobby: burning massive amounts of compute on AI coding ... to save the genomics community even more compute.
Picard is super excited for a new aligner from Heng Li
Riker tools are 1.6-3.64x faster in release 0.2.0 vs. 0.1.0
Benchmarking results on a 2.5G SAM file at AWS showing 3.75-4.75X faster compression and 2-2.7X faster decompression than the JDK's built in methods.
We're attending ASHG in Boston this October - if you're going too, let us know!
Fulcrum Genomics will be at AGBT, February 23-26 2025. Let's talk!