the Node

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the Node is a community site for and by developmental and stem cell biologists, covering news, meetings, and research. Hosted by Development @dev-journal.bsky.social @biologists.bsky.social. #DevBio #StemCell https://thenode.biologists.com

Development presents... Wednesday 25 February – 15:00 GMT/UTC Chair: Polina Kameneva Joaquín Navajas Acedo (University of Basel) ‘Spatiotemporal emergence of somatosensory neuron diversity’ Carlo Donato Caiaffa (Universidade de São Paulo) ‘Decoding the role of HNRNPH2 in neural development using brain organoids and antisense oligonucleotides’ Clarisse Brunet (Institut Curie) ‘Decoding the gliogenic switch: how human brain organoids reveal the secrets of glial cell fate’ #DevPres @dev-journal.bsky.social theNode.biologists.com/devpres The Company of Biologists logo Development logo QR code
Flyer for “Development presents…” science talks on 14 January at 15:00 GMT. Speakers: Chee Kiang Ewe, Max Farnworth, Sonya Widen. Topics include C. elegans sterility, butterfly cognition, and gene transfer. Includes headshots, tissue image, and event details.
Screenshot of the Events Calendar available on the Node showing two events happening in November 2025.
Writing challenge the Node logo to the left Post on the Node before 30 September and win £200 to the right
Development cover: Embryonic eye of an anole lizard stained for nuclei (DAPI, blue) and F-actin (Phalloidin, orange), imaged by spinning disc confocal microscopy and processed using ImageJ. The image was acquired at the 2025 MBL Embryology course by Arthur Boutillon and was the Editor's choice from the Node image competition.
Ingrid Tsang
Writing challenge the Node logo to the left Post on the Node before 30 September and win £200 to the right
Development presents… Wednesday 27 August 15:00 BST Chair: James Gaham Anzy Miller (University of Manchester) ‘NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiation’ Marlies Oomen (Helmholtz Munich, Institute of Epigenetics and Stem Cells) ‘Jumping through evolution; Genome regulation of and by transposable elements during mammalian preimplantation development’ #DevPres | @dev-journal.bsky.social thenode.biologists.com/devpres The Company of Biologists logo Development
The skin of a frog embryo, with cilia (in magenta and cyan) and the outline of cells (in grey) highlighted. Image credit: James Schmidt
Development presents… Wednesday 13 August 16:00 BST Chair: Yuchuan Miao Image of Toshi Yamada Toshi Yamada (University of California San Francisco) ‘Synthetic organizer cells guide development via spatial and biochemical instructions’ Image of Chrysanthi-Maria (Anthie) Moysidou (Max Delbrück Center) Chrysanthi-Maria (Anthie) Moysidou (Max Delbrück Center) ‘Bioelectronics meet neuromuscular organoids: novel tools for enhancing the maturation and complexity of organoids’’ Image of Daniel Medina-Cano Daniel Medina-Cano (MSKCC) ‘A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro’ #DevPres |@dev-journal.bsky.social Thenode.biologists.com/devprev The Company of Biologists logo Development logo QR code to register Development presents… Wednesday 13 August 16:00 BST Chair: Yuchuan Miao Image of Toshi Yamada Toshi Yamada (University of California San Francisco) ‘Synthetic organizer cells guide development via spatial and biochemical instructions’ Image of Chrysanthi-Maria (Anthie) Moysidou (Max Delbrück Center) Chrysanthi-Maria (Anthie) Moysidou (Max Delbrück Center) ‘Bioelectronics meet neuromuscular organoids: novel tools for enhancing the maturation and complexity of organoids’’ Image of Daniel Medina-Cano Daniel Medina-Cano (MSKCC) ‘A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro’ #DevPres |@dev-journal.bsky.social Thenode.biologists.com/devprev The Company of Biologists logo Development logo QR code to register
Two text bubbles in yellow and blue on the left and the Node logo on the right. Text reads "Honest conversations: creating frank conversations around less-discussed topics on the Node"
Screenshot of the Node's Jobs Board. Text reads: Welcome to the developmental and stem cell biology jobs board. The board shows only active job adverts – expired adverts will be moved to the jobs archive.
Development presents... Wednesday 9 July 15:00 BST, chaired by Alex Eve. Talk 1: Lakshmi Balasubramaniam (Gurdon Institute) ‘Tissue spreading couples matrix remodelling during avian gastrulation’ Talk 2: André Dias (Universitat Pompeu Fabra) ‘Opposing Nodal and Wnt signalling activities govern the emergence of the mammalian body plan’ Talk 3: Nikhil Mishra (Institute of Science and Technology Austria) ‘Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo’
Development presents... Wednesday 9 July 15:00 BST, chaired by Alex Eve. Talk 1: Lakshmi Balasubramaniam (Gurdon Institute) ‘Tissue spreading couples matrix remodelling during avian gastrulation’ Talk 2: André Dias (Universitat Pompeu Fabra) ‘Opposing Nodal and Wnt signalling activities govern the emergence of the mammalian body plan’ Talk 3: Nikhil Mishra (Institute of Science and Technology Austria) ‘Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo’
Screenshot of the Node's Jobs Board. Text reads: Welcome to the developmental and stem cell biology jobs board. The board shows only active job adverts – expired adverts will be moved to the jobs archive.
The two designs of the Node coasters. Image credits: Evan Bardot (mouse embryo) and Gonzalo Aparicio (zebrafish retina). Text reads: Visit The Company of Biologists booth at SDB 2025 to pick up some free goodies from us and find out about joining the Node Network. Email: thenode@biologists.com. X: @the_Node. Bluesky: @the-node.bsky.social
The cartoon was done for German BioImaging (GerBI-GMB) to illustrate the enabling power of research data management (RDM)
The two designs of the Node coasters. Image credits: Evan Bardot (mouse embryo) and Gonzalo Aparicio (zebrafish retina). Text reads: Visit The Company of Biologists booth at SDB 2025 to pick up some free goodies from us and find out about joining the Node Network. Email: thenode@biologists.com. X: @the_Node. Bluesky: @the-node.bsky.social
Development presents... Wednesday 4 June 15:00 BST. BSDB poster prize winners. Chair: Abigail Tucker. Talk 1: Giulia Paci (University College London) ‘3D cell topology regulates signalling range to promote precise patterning of wing sensory organs’ Talk 2: Shifaan Thowfeequ (University of Oxford) ‘Visualising calcium dynamics in the developing embryo : from fertilisation to the first heartbeat’
Image shows two speech bubbles in yellow and blue, the Node logo and the text: "Have your say - take our survey and help shape the future of the Node."
Screenshot of the Node's Jobs Board. Text reads: Welcome to the developmental and stem cell biology jobs board. The board shows only active job adverts – expired adverts will be moved to the jobs archive.
Image shows two speech bubbles in yellow and blue, the Node logo and the text: "Have your say - take our survey and help shape the future of the Node."
Steampunk Zebrafish Embryo – Digital artwork representing the dynamic world of Cell and Developmental Mechanobiology, blending biological accuracy with a steampunk aesthetic.
Image shows two speech bubbles in yellow and blue, the Node logo and the text: "Have your say - take our survey and help shape the future of the Node."
Image shows two speech bubbles in yellow and blue, the Node logo and the text: "Have your say - take our survey and help shape the future of the Node."
Development presents... Wednesday 28 May 15:00 BST. Outstanding paper prize finalists. Chair: Alex Eve. Talk 1: Bridget LaMonica Ostrem (University of California, San Francisco) ‘Microglial memory: Shaping the fetal brain response to maternal inflammation’ Talk 2: Thamarai Athilingam (University of Warwick) ‘Concentration dependent diffusion dynamics of Bicoid in the early Drosophila embryo’ Talk 3: Kevin Emmerich (NIH/NHLBI Translational Vascular Medicine Branch) ‘A large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration’
A ‘Cell-estial Bloom’ of human induced pluripotent stem cells (hiPSCs) flourishes on a micropatterned island. This image presents a colony of live hiPSCs, with fluorescently labeled Lamin B delineating the nuclear lamina within each cell. Acquired with a Zeiss LSM 880 Airyscan microscope, this maximum intensity projection is enhanced with depth-coded coloring to reveal the captivating three-dimensional landscape.
Arabidopsis genetics. 6 stages of Arabidopsis rosettes arranged into 2 helices. Hand printed Spring 2024.
Collage of the five different header images, shown from top to bottom. Image descriptions: 1. Zebrafish lymphatics by Daniel Castranova. Lymphatic vessels shown in blue and neutrophils shown in orange in the head of a double transgenic juvenile zebrafish. 2. Catshark by Rory Cooper. Cleared and alizarin and stained hatchling catshark embryo. 3. Preimplantation mouse embryos by Markus Schliffka. Different stages of mouse preimplantation development from the zygote to the blastocyst, with nuclei in cyan and actin in grey. 4. Zebrafish retina by Gonzalo Aparicio. Retina from a 72hpf zebrafish embryo. Photoreceptor marker shown in red, while gfap:eGFP (a Muller cell marker) is shown z-depth pseudo-coloured. 5. Mouse embryo by Evan Bardot. Cleared E12.5 embryo labelled with antibodies against Cntn2 (green) and ColIV (magenta). Generated in Collaboration with James Muller.
Two text bubbles in yellow and blue on the left and the Node logo on the right. Text reads "Honest conversations: creating frank conversations around less-discussed topics on the Node"
Image shows two speech bubbles in yellow and blue, the Node logo and the text: "Have your say - take our survey and help shape the future of the Node."
Image shows two speech bubbles in yellow and blue, the Node logo and the text: "Have your say - take our survey and help shape the future of the Node."
Actinotroch larva of a phoronid worm with phalloidin shown in yellow and acetylated tubulin in magenta. Imaged with a Zeiss LSM 800 at 10 x magnification
The image depicts a zebrafish embryo at 9 hours post-fertilisation on a lateral view. Cells are stained with MitoTracker, which labels active mitochondria, and cell membranes are labelled in cyan with a EGFP transgenic membrane tag. Image was taken using a 20x objective on a spinning disk confocal microscope.
Supplementary movie 1. from Lebedeva et al. Live imaging of the sfGFP-β-catenin dynamics during development of the Nematostella embryo until the onset of gastrulation. Note that nuclear sfGFP-β-catenin is visible in the interphase of every cell cycle until mid-blastula at the side opposite to where the mesoderm will form and start to invaginate.
John Mains-Sheard posing with the Node's polaroid frame in front of his poster. On the frame the text reads "John Mains-Sheard #stemcell #limb #DevBio"
Qamariya Nasrullah and her little one posing with the Node's polaroid frame, in front of her poster. On the frame the text reads: Qamariya Nasrullah #EvoDevo # reptiles #womeninSTEMM"
Nadisha Gamage posing with the Node's polaroid frame in front of her poster. The text on the frame reads: "Nadisha Gamage #nucleosomes #cryoelectronmicroscopy #stemcells #chromatin #fibsem"
Aymen al-Rawi posing with the Node's polaroid frame. The text on the frame reads "#ECR #CircadianRhythm #MassSpec #MRC_LMB"
"Cell-estial bloom" Image from Özge Özgüç: A ‘Cell-estial bloom’ of human induced pluripotent stem cells (hiPSCs) flourishes on a micropatterned island. This image presents a colony of live hiPSCs, with fluorescently labelled Lamin B delineating the nuclear lamina within each cell. Acquired with a Zeiss LSM 880 Airyscan microscope, this maximum intensity projection is enhanced with depth-coded coloring to reveal the captivating three-dimensional landscape.
Anahi Binagui-Casas posing with the Node's polaroid frame in front of a roller banner and window. On the frame the text reads "Anahi Binagui-Casas #embryo #axiselongation #endothelia #ECR"
Vedansh Challa posing with the polaroid frame in front of a black poster board. On the frame the text reads "Vedansh Challa #astrocytes #RNAi"
Kavitha Chinnaiya posing with the polaroid frame in front of her poster. On the frame the text reads "Kavitha Chinnaiya #hypothalamus #ChickEmbryo #homeostasis #BMP #FGF10 #Shh"
Photo of Pleasantine Mill
Martina Boiardi and Nicole Goede posing with the polaroid frame in front of a roller banner about the Node. On the frame the text reads "Martina Boiardi and Nicole Goede #GelensLab #DiBS #Xenopuslaevis #CellCycle"
Video of someone going down the escalator and approaching the image gallery of the Node-FocalPlane image competition, located at the entrance of Hall 2 of the Biologists @ 100 conference. A big 100 sign is also in frame on the left.
the Node's conference reporter, Jen Annoh, posing with the polaroid frame in the atrium of the conference venue. On the frame the text reads "Jen Annoh #Wnt3". Behind Jen is a roller banner about The Company of Biologists.
Collage of the five different header images, shown from top to bottom. Image descriptions: 1. Zebrafish lymphatics by Daniel Castranova. Lymphatic vessels shown in blue and neutrophils shown in orange in the head of a double transgenic juvenile zebrafish. 2. Catshark by Rory Cooper. Cleared and alizarin and stained hatchling catshark embryo. 3. Preimplantation mouse embryos by Markus Schliffka. Different stages of mouse preimplantation development from the zygote to the blastocyst, with nuclei in cyan and actin in grey. 4. Zebrafish retina by Gonzalo Aparicio. Retina from a 72hpf zebrafish embryo. Photoreceptor marker shown in red, while gfap:eGFP (a Muller cell marker) is shown z-depth pseudo-coloured. 5. Mouse embryo by Evan Bardot. Cleared E12.5 embryo labelled with antibodies against Cntn2 (green) and ColIV (magenta). Generated in Collaboration with James Muller.
Text at the top reads: The Node is your site. Do you have something to share? Community news, meeting reports, research stories, jobs and events - you can post freely on the Node. Bottom image shows a hatchling catshark embryo. Image credit: Rory Cooper
Figure from Editorial "Development: a journal's journey", showing cover styles of Journal of Embryology and Experimental Morphology (JEEM) and Development through the decades.
Text reads: "The Node-FocalPlane image competition. Shortlisted images will be displayed at Biologists @ 100, 24-27 March 2025, ACC Liverpool, UK. Submit your images by 24 February 2025". The image shows a mouse embryonic fibroblast labelled with phalloidin in green, green), acetylated tubulin in magenta and DAPI in blue.
A screenshot of the Node's Jobs Board. Top half of the image shows the Node logo and text: the community site for and by developmental and stem cell biologists". Bottom half text reads "Welcome to the developmental and stem cell biology jobs board. The board shows only active job adverts – expired adverts will be moved to the jobs archive."
Image showing two speech bubbles and the Node logo. Text reads: Honest conversations: creating frank conversations around less-discussed topics on the Node
Cover image of issue 16: A superimposition of three stages of embryonic mouse lungs (E12 in white, E13 in cyan and E14 in magenta) demonstrating changes that can be observed over a 3-day period. The pulmonary mesenchyme regulates the lengthening and widening of airways via the protein Vangl2, revealing a previously unreported role for this tissue compartment in the shaping of the airway tree. See Research article by Paramore et al.
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Collage of the 24 Development cover images in 2024