Trenton Dailey-Chwalibóg

@trenton.phd

887 Followers 1182 Following

#Epidemiologist · #MultiOmics · #MNCH · #Microbiota · #EED · #HumanMilk · #UGent · #AFRICSanté · #BrusselsGriffons

Summary Early-life gut microbiome development is shaped by complex maternal and nutritional influences, yet the temporal and directional structure of these interactions remains unclear. In a longitudinal study of 152 mother-infant dyads in rural Burkina Faso, we examine how maternal gut and milk microbiomes, alongside milk components, influence infant gut microbiome development during the first 6 months. At 1–2 months, the infant gut microbiome clusters into three types: Escherichia-dominated, Bifidobacterium-dominated, and a diverse, pathogen-prevalent profile, which become less distinct by 5–6 months. Early infant gut microbiomes associate with maternal prenatal gut microbiota and early milk microbiome and oligosaccharides, while later variation links to other milk nutrients. Furthermore, early infant gut profiles predict subsequent milk composition, suggesting potential bidirectional communication between infant needs and maternal lactational physiology. These findings offer insights into early-life microbial development and inform future mechanistic studies and microbiome-targeted interventions, particularly in low-resource settings.
This is a picture of (left to right) Lionel, me, Yuri and Thanos enjoying "porc au four" and beer on a Sunday during a field visit to Burkina Faso.
Disclaimer: The content of this podcast was generated using artificial antelligence, based on prompting and providing information from the study. While it offers a general overview of the research, it may not capture every detail with full accuracy. For comprehensive and precise information, please refer to the peer-reviewed article. 📑
This is my one-year-old Petit Brabançon (smooth-coat Brussels Griffon in English) puppy, Precious Angel Baby. She goes by “Baby” for short. She weighs 3.25 kg but is very sassy and extremely stubborn-headed. She loves Comté, French fries, and running off-leash in the grass—but above all, she loves crawling back into bed with her daddies after her morning walk and sleeping until at least 11:00 a.m on the weekends 🐕