Viki Male

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Immunology of the menstrual cycle and pregnancy.

A Kaplan Meier curve displaying time to childbirth by COVID vaccination status. There is no difference between the two groups.
Analysis of cost-effectiveness of COVID vaccination in different age and risk groups, from the CDC presentation linked in the post. Vaccination is cost-saving in at risk over 65, so long as it costs less than $90/dose.
A slide from the CDC presentation linked in the post. Graph showing that the rate of COVID hospitalisation is similar in babies under 6 months and adults over 65.
Slide from the CDC presentation linked in the post above. Results from test negative case control studies showing COVID vaccination in pregnancy is approximately 55% effective against hospitalisation with COVID in infants under 2 months old.
Slide from the CDC presentation linked in the post. Results from test negative case control studies showing COVID vaccination is approximately 40% effective against hospitalisation with COVID in non-pregnancy immunocompetent women, and 60% among pregnant women. The error bars of the two estimates overlap.
A slide presented at the 18 September ACIP meeting (linked in the post). Links to CDC run studies on COVID vaccine safety in pregnancy. A list of outcomes not associated with COVID vaccination in pregnancy in these studies, including miscarriage, stillbirth, preterm birth, major birth defects, maternal or infant ICU admission.
Screenshot of the title of the paper cited in support of this claim. “COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals”
Screenshot of the title and abstract of the paper cited in support of this claim (and linked in the post). The title is: Safety of SARS‑CoV‑2 vaccination during pregnancy‑ obstetric outcomes from a large cohort study.
Table 2 from the paper, showing the risk of miscarriage is the same in the unvaccinated, vaccinated before pregnancy and vaccinated during pregnancy groups, once differences in age and health are taken into account.
Table 1 of the paper, showing differences in age, socioeconomic status and comorbidities between the groups
Screenshot of the title and abstract of the paper cited in support of this claim (and linked in the post). The title is: Miscarriage after SARS-CoV-2 vaccination: A population-based cohort study. “Conclusion: SARS-CoV-2 vaccination was not associated with miscarriage” is highlighted in the abstract
A slide summarising the safety data on COVID infection and vaccination in pregnancy. On the left, in unvaccinated individuals COVID infection increases the risk of preterm birth, pre-eclampsia, stillbirth and neonatal death. On the right: 3 trials including 221 participants who received mRNA vaccine and 49 observational studies including at least 523,429 people vaccinated in pregnancy found no increased risk of stillbirth, miscarriage, preterm birth, SGA, congenital abnormalities, NICU admission or health or neurodevelopmental problems in babies up to eighteen months old, following COVID vaccination.
Screenshot of the header of Secretary Kennedy’s justification for repealing the recommendation for COVID vaccination to children and pregnant individuals (linked in the post).
A slide summarising the safety data on COVID infection and vaccination in pregnancy. On the left, in unvaccinated individuals COVID infection increases the risk of preterm birth, pre-eclampsia, stillbirth and neonatal death. On the right: 3 trials including 221 participants who received mRNA vaccine and 49 observational studies including at least 523,429 people vaccinated in pregnancy found no increased risk of stillbirth, miscarriage, preterm birth, SGA, congenital abnormalities, NICU admission or health or neurodevelopmental problems in babies up to eighteen months old, following COVID vaccination.
Slide from the CDC presentation, showing an increased risk of hypertension (1.09), pre-eclampsia (1.12) or gestational hypertension (1.10) but not eclampsia or HELLP (0.77) in the vaccinated cohort.
A slide from the CDC presentation of the simulated trial. Among 13,966 vaccinated individuals, the preterm birth rate was 4.0%. Among 13,966 unvaccinated individuals, the rate was 4.5%.
PhD student Abigail Goodship with her crowdsourced poster on how health changes over the menstrual cycle.
A google search asking about "robs vs robins". The AI overview says that "Robs refers to a risk of bias tool, specifically the Cochrane Risk of Bias tools. Robins refers to bird species, like the American Robin or European Robin."
The footnote referred to in the original post. Contrary to all reasonable expectations, it is not a Rickroll.
A screenshot of text from an ebook. There is a clickable footnote associated with the word “Rickrolling”.
Half a glass of red with on a coffee table, with a jar of fairy lights in the background
Two graphs show the mean symptom score reported by people living with Long COVID or ME/CFS. The left graph shows menstrual cycle phase, with symptoms most severe before and during the menstrual period, and least severe at around the time of ovulation. The right graph shows less severe symptoms in people taking combined hormonal contraception, compared to none or progestin only.
Austin Powers Dr Evil air quotes meme “Flow Cytometrist”
The cover of the Penguin Classics edition of The Master and Margarita by Mikhail Bulgakov. In shadow puppets, a cat with red eyes is seen beheading a man in a suit.
The cover of The House of the Spirits by Isabel Allende.
The cover of Beloved by Toni Morrison. Pink and orange branches, on a burgundy background.
An eight-year-old girl’s single bed, with Lego and geodes piled up in the headboard
Christmas in Exeter Street by Diana Hendry (and a bit of my Christmas tree!)
The cover of Grass by Sherri S Tepper.
The cover of Hyperion by Dan Simmons.
The cover of Bridget Jones’s Diary by Helen Fielding - 90s edition.
The cover of Going Solo by Roald Dahl. Illustrated by Quentin Blake.
The cover of Foundation by Isaac Asimov, my 2000 edition.
The cover of The Doomsday Book by Connie Willis.
The cover of The Researcher’s First Murder by John Finnemore
The cover of The Talented Mr Ripley by Patricia Highsmith.
A copy of “The Subtle Knife” by Philip Pullman, open on my kitchen counter.
The cover of The Left Hand of Darkness by Ursula Le Guin
The cover of A Suitable Boy by Vikram Seth. (And part of my Christmas tree!)
The cover of Catch-22 by Joseph Heller.
The cover of Timescape by Gregory Benford
Figure 2 from the recently published paper on the discovery of a sabre tooth kitten in permafrost. The head of the kitten is shown in profile. It looks similar to a lion cub, with red-brown fur. It does not yet have its sabre teeth.
Screenshot of the title of the linked paper Four simple ways to increase power without increasing the sample size By Stanley E Lazic
Screenshot from the JCVI minutes noting that the committee is supportive of efforts to increase the uptake of other vaccines given in pregnancy.
Screenshot from the JCVI minutes, linked in post 3 above, saying that there is significant uncertainty in their estimates of the value of COVID vaccines for pregnant individuals.
Screenshot from the link above, saying that JCVI does not know the cost of vaccines next Autumn since the information is “commercially confidential”
Screenshot from the JCVI’s minutes (linked in post 3 above) giving the costs quoted in this post at which COVID vaccines in pregnancy are “good value”.
Screenshot from the JCVI minutes, linked in post 3 above, showing that vaccination of fewer than 500 pregnancies are needed to prevent hospitalisation of one infant with COVID.