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#LongCovid since May 9, 2022. I was out for my morning run when exhaustion hit me. PEM, orthostatic intolerance, etc Last #SARSCov2 infection: April 2022. Medical news https://m.youtube.com/@VirusSucks-com/shorts #COVID is airborne so ventilate

https://www.guelphtoday.com/local-news/local-family-files-11m-suit-against-guelph-hospital-six-doctors-12579648 A patient, who is also a doctor at Guelph General Hospital, is seeking damages related to the care she received after she was injured playing hockey last year A Guelph family is seeking $11.1 million in a lawsuit filed against Guelph General Hospital and six of its doctors for the way a woman, who is also a doctor at the hospital, was treated in the wake of an injury she sustained while she was playing hockey last year. It should be noted the woman, and her husband, are also doctors. The patient in this case is an emergency physician and trauma medical doctor at GGH. Her husband is listed in court documents as a practising physician. Their two children are also listed as plaintiffs in the suit. Four of the six doctors listed as defendants in the suit are surgeons. The other two are anesthesiologists. It all goes back to July 26, 2025. The woman suffered what was described as “a traumatic injury” to her lower right leg while playing hockey, and was rushed to hospital in an ambulance. According to the claim, the woman reported “severe right lower leg pain” when she was in the emergency department. She had surgery the next day to repair a “comminuted spiral fracture of the mid-to-distal right tibia with mild medial displacement and intra-articular extension into the ankle joint.” After surgery, the woman’s husband asked the surgeon if he was concerned about the risk of postoperative acute compartment syndrome, or ACS. ACS is described by the Canadian Journal of Surgery as a "clinical condition" that can develop in any of the four compartments of the leg. "It is advocated that the main clinical symptom of a developing ACS is pain," the journal states. "Palpable tenseness, paresthesia, paresis and pulselessness may also be associated with compartment syndrome." The statement of claim says the surgeon dismissed the concern, believing he was satisfied…
Karius testing is a next-generation sequencing assay available for infectious disease testing in the United States since 2017 (11). It measures microbial cell-free DNA in blood to detect at least 1250 different bacteria, viruses, fungi, and parasites (12). It offers a noninvasive approach, with rapid turnaround and greater sensitivity than blood cultures. https://www.acpjournals.org/doi/10.7326/aimcc.2026.0253
Kalshi to offer betting on drug trial results and FDA regulatory decisions Move comes as prediction platforms rapidly gain popularity and offer opportunities to bet on virtually anything Gaya Gupta Thu 16 Jul 2026 Kalshi is expanding its wagers to include bets on drug trial results, an expansion into new predictions territory as platforms continue to rapidly gain popularity and offer opportunities to bet on virtually anything. The betting platform said the expansion into clinical trials and FDA regulatory decisions would help surface information on drug trials that otherwise go unreported. A publicly listed contract on a drug trial would produce a “continuously updated, public probability that reflects the weight of the evidence, rather than the preferred message of the trial sponsor”, the company said. “Drug development is one of the most important and most information-constrained industries on earth,” Kalshi’s CEO, Tarek Mansour, said in a statement. “The data that determines which drugs advance and which don’t is largely locked away from the people who need it most. Surfacing information is what Kalshi is for, and we are committed to doing it right: compliance-first, carefully scoped, and built for the long term.” The launch is described as a pilot program, and was announced as a partnership with the artificial intelligence firm AppliedXL. Critics have said prediction platforms such as Kalshi are at risk of market manipulation and insider trading. Federal regulators told CBS News on Friday that Donald Trump’s longtime teleprompter operator made tens of thousands of dollars on bets around the president’s speeches. Last month, the Department of Justice launched an investigation into George Santos, the former Republican congressman from New York, over whether he engaged in insider trading by betting on his own attendance at the State of the Union address. And in April, several congressional candidates were fined for betting on the outcomes of their own races.
A meta-analysis of six studies with 175 patients at least 3 weeks after the diagnosis of COVID-19 and 275 healthy individuals Sobrino-Relano et al. [65] found that individuals who had recovered from COVID-19 showed significant cognitive deficits compared to controls. A further systematic review of 7912 COVID-19 survivors two years after the infection reported cognitive impairment in 27.6% of the cases [66]. Finally, a systematic review of 12 cohort studies involving 2.7 million post-COVID cases and 30 million controls found a 50% increased risk for newly diagnosed AD, and 44% increase in the risk of newly diagnosed PD at 3–24 months after recovering from COVID-19. The authors suggested developing a comprehensive surveillance program for neurodegenerative diseases in recovered COVID-19 patients [67]. It should be noted that several confounding factors could not be considered in this meta-analysis, and some patients might have already suffered from AD or PD, which was unmasked or identified when these persons sought for medical help due to COVID-19 https://link.springer.com/article/10.1007/s00415-025-13110-3
In conclusion, (+)[11C]DTBZ BPND were lower in the ventral striatum, dorsal putamen and dorsal caudate in adults with long COVID. Lower ventral striatal (+)[11C]DTBZ BPND correlated with apathy and cognitive concerns. Lower dorsal putamen (+)[11C]DTBZ BPND correlated with motor slowing and lower dorsal caudate (+)[11C]DTBZ BPND correlated with worse verbal memory performance. These symptoms that correlated with reductions in (+)[11C]DTBZ BPND are also important neuropsychiatric symptoms of long COVID. The magnitude of (+)[11C]DTBZ BPND loss in long COVID is similar to other illnesses with common pathology and symptoms, such as the ventral striatum and caudate of mild to moderate Parkinson's disease and the dorsal putamen of REM sleep behaviour disorder).23,24,26 Given the heterogeneity of long COVID, future studies in larger, similarly well-controlled cohorts would help confirm the robustness and generalisability of these findings. Such studies could also test whether interventions aimed at restoring dopamine-releasing synapses and/or augmenting tonic and phasic dopamine release in the ventral striatum, dorsal putamen, and dorsal caudate influence correlated symptoms in long COVID. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964%2826%2900222-7/fulltext
Covid leaves lasting brain damage that flu does not
The sentence includes 12 months of house arrest, with exceptions for medical emergencies involving family, travel for employment, legal obligations, medical appointments, and religious services. She is permitted up to five hours per week for necessities of life and may be present for the birth of her grandchild. For the remaining 3.5 months, Lich will be subject to a curfew. Additionally, she must complete 100 hours of community service. https://www.thedemocracyfund.ca/tamara_lich_receives_conditional_sentence_in_freedom_convoy_mischief_case#gsc.tab=0
The tumor microenvironment surrounds the pancreatic cancer cells in red, consisting of immune cells (green), fibroblasts, endothelial cells (lining of blood vessels, and matrix. Recently, Professor Aaron Newman at Stanford and colleagues from many US leading centers published a landmark paper in Nature. It may ultimately be considered one of the most important leaps in cancer diagnostics in decades. Ground Truths is a reader-supported https://erictopol.substack.com/p/a-breakthrough-blood-test-for-cancer
"Tomorrow and Tomorrow...Studies of the Neuropathogenesis of Long COVID - Serena Spudich, MD" on YouTube https://youtu.be/vhR-8RV-ymo Presenter: Serena Spudich, MD, Yale University, United States https://scholar.google.com/citations?hl=en&user=rx17xoAAAAAJ&view_op=list_works&sortby=pubdate Lecture: Tomorrow, and Tomorrow, and Tomorrow... Studies of the Neuropathogenesis of Long COVID Presented in Session 5: Diagnostics, Biomarkers, and End Points Demystifying Long COVID International Conference 2024 Autoimmunity: While an initial case of psychosis post-COVID responded miraculously to IVIG and showed a novel anti-neuronal antibody (15:56-17:02), a larger survey revealed no significant differences in autoantibody recognition between post-COVID recovered and Long COVID groups, indicating that many people with COVID might have autoantibodies recognizing brain tissue without symptoms (17:05-17:36). Viral Persistence: The study found no evidence of SARS-CoV-2 antigen persistence in CSF using nucleic capsid antigen or PCR (17:39-18:05). Plasma Markers and Brain Imaging (18:07-20:55): Acute Phase Proteins and Coagulopathy: Long COVID patients showed persistent abnormalities in acute phase proteins and coagulopathy markers in plasma, often falling between acute hospitalized COVID patients and post-COVID recovered individuals (18:07-19:23). Endotheliopathy and Platelet Activation: Endotheliopathy and platelet activation markers were persistently elevated in Long COVID, suggesting ongoing vascular issues (19:25-19:37). These markers also correlated with cognitive domains, particularly verbal learning (19:53-20:02). Neuroimaging (Lindsay McAlpine's Work): Preliminary findings from neuroimaging suggest brain atrophy, changes in white matter tract integrity, and altered regional brain perfusion in Long COVID patients. Research is also exploring the lymphatic and glymphatic systems of the brain (20:06-20:55).
A U.S. federal judge has blocked Louisiana’s proposed social media age verification law, delivering a setback to state-level efforts aimed at regulating online access for minors. The law, formally titled the Secure Online Child Interaction and Age Limitation Act, was scheduled to begin enforcement within days, despite having technically taken effect on July 2025; however, state officials agreed not to enforce it until December 19, 2025. The legislation was passed in 2023 and would have compelled social media and content-sharing platforms, such as Meta, Reddit, Snap, YouTube, and Discord, to have age verification systems and parents’ consent policies in place. It was aimed at restricting children’s access to harmful materials on the Internet, such as pornography and other explicit material, and enhancing the level of child safety on the web. Judge John W. deGravelles has ruled that the law had constitutional issues. He claimed that both the age verification and parental consent clauses were over- and under-inclusive, as well as criticized the statute in general for a broad definition of what constitutes a social media platform. The court said that such uncertainty posed a risk to inconsistent application and excessive load on platforms and users. The ruling is a major victory for NetChoice, a trade association in the technology industry, that appealed the law. NetChoice claimed that the law violated First Amendment rights and posed privacy and security concerns tied to collecting sensitive identity data for access to speech online. On the verge of the ruling, NetChoice pointed out that poorly crafted age assurance mechanisms may have unintended effects. The group cautioned that mandatory age verification, without privacy-preserving technologies, would expose users to data misuse and surveillance risks. It also referred to overseas cases in which such laws have ... https://shuftipro.com/news/federal-judge-blocks-louisiana-social-media-age-verification-law/
https://ag.ny.gov/press-release/2026/attorney-general-james-secures-more-50-million-eggs-and-33-million-after Attorney General James Secures More Than 50 Million Eggs and $3.3 Million After Uncovering Illegal Scheme To Manipulate Egg Prices Attorney General James Secures More Than 50 Million Eggs and $3.3 Million After Uncovering Illegal Scheme to Manipulate Egg Prices Investigation into Nation’s Largest Egg Producers Revealed Illegal Scheme That Raised Costs for Consumers and Businesses June 29, 2026 NEW YORK – New York Attorney General Letitia James today secured more than 50 million eggs for consumers nationwide and $3.3 million from some of the nation’s largest egg producers for colluding behind the scenes to raise prices. A bipartisan multistate investigation led by the Office of the New York Attorney General (OAG) alongside the U.S. Department of Justice (DOJ) revealed that Cal-Maine Foods (Cal-Maine), Versova/Centrum (Versova), and Hickman’s Egg Ranch (Hickman’s) illegally coordinated for years to influence a daily price index for eggs, which artificially increased prices for retailers and consumers throughout the country. Of the 53 million eggs obtained through the settlement, approximately 4.9 million eggs will be delivered directly to food banks and community organizations serving New Yorkers. “When powerful corporations collude behind the scenes to raise prices, working families suffer the costs,” Attorney General James. “These egg producers manipulated the market to squeeze even more profit out of consumers and businesses. By shutting this scheme down and delivering millions of eggs to those in need, we’re sending a clear message that companies will not get away with illegal price hikes in New York.”
Sarcoidosis, also known as Besnier–Boeck–Schaumann disease, is a non-infectious granulomatous disease involving abnormal collections of inflammatory cells that form lumps known as granulomata. The disease usually begins in the lungs, skin, or lymph nodes. Less commonly affected are the eyes, liver, heart, and brain, though any organ can be affected. The signs and symptoms depend on the organ involved. Often, no symptoms or only mild symptoms are seen. When it affects the lungs, wheezing, coughing, shortness of breath, or chest pain may occur. Some may have Löfgren syndrome, with fever, enlarged hilar lymph nodes, arthritis, and a rash known as erythema nodosum. The cause of sarcoidosis is unknown. Some believe it may be due to an immune reaction to a trigger such as an infection or chemicals in those who are genetically predisposed. Those with affected family members are at greater risk. Diagnosis is partly based on signs and symptoms, which may be supported by biopsy Continued in Wikipedia Usual onset 20–50 years old, More common in women Duration Few years to long term Causes Unknown Risk factors Family history Diagnostic method Based on symptoms and tissue biopsy Differential diagnosis Tuberculosis, lymphoma, infectious mononucleosis, pulmonary eosinophilia Treatment Ibuprofen, prednisone, methotrexate Prognosis Mortality 1–7%
giving a group of ministers the ability to disregard Health Canada's safety decisions. "Politicians should be very careful before substituting political judgment for scientific expertise," Galvez said in the Senate on Thursday, pointing to the growing and extensive research linking pesticide exposure to increased risks of cancer, reproductive and neurological issues. Galvez also noted that scientists, public health and environmental experts were not given the chance to testify in front of Parliament. Health and environment committees also did not study the legislation. "For a reform of this magnitude, that should concern us," she said.
Reflecting Pool renovations to cost more than $16 million June 19, 2026 The cost to repaint the Lincoln Memorial Reflecting Pool has ballooned to more than $14.65 million — exceeding the original estimated cost of the no-bid contract by more than $4 million, according to federal contract data. In addition to the repainting by Atlantic Industrial Coatings, the National Park Service paid $1.74 million to Green Water Solutions, an Ohio-based company, earlier this year to install a “nano bubble” system to kill algae, using a similar no-bid contract to speed up the work in time for Fourth of July celebrations. Between the two companies that received separate contracts for the resurfacing and filtration systems, the project is set to cost more than $16 million. The status of the payments to the contractors was not immediately available in the federal government’s contract database. The Interior Department said in a statement via X, “The advanced nanobubbler technology very effectively killed the algae that has plagued every Lincoln Reflecting Pool reopening—most infamously Obama’s reopening—since 1922. The Reflecting Pool water is crystal clear, and our National Park Service team is now vacuuming up the dead algae resting on the bottom of some parts of the Reflecting Pool—just like the destroyed Iranian Navy resting on the bottom of the Persian Gulf.” Trump has repeatedly defended the project, though the new paint job — described in the contract documents as a “seamless, monolithic, waterproof, antimicrobial, and anti-algae system suitable for continuous submersion” — and appears to be peeling, and an algae bloom has overtaken the reflecting pool. “As a developer, I’ve probably built more than 100 swimming pools in different buildings I built, and I have some really good pool builders,” Trump said in April about the project. “They’re great people. I have such great https://www.wsjm.com/2026/06/19/reflecting-pool-renovations-to-cost-more-than-16-million/
During the acute phase of SARS-CoV-2 infection, COVID-19 patients are at high risk of thrombotic events, accompanied with elevated biomarkers levels such as D-dimer. Supporting this notion, a multicenter and prospective cohort study of 295 patients demonstrated that the incidence of thrombotic events was significantly higher in patients with COVID-19 (n=150) than in non-COVID-19 patients (n=145) (11.7% vs. 2.1%, P < 0.008), with elevated D-dimer levels observed in more than 95% of patients (81). Similarly, a multicenter and cross-sectional study involving 384 COVID-19 patients 4-6 weeks after discharge reported that 30.1% had persistently elevated D-dimer levels (82). Beyond the acute phase of COVID-19, the risk of thrombotic events increases significantly in Long COVID patients. A retrospective cohort study from the TriNetX US Collaborative Network demonstrated that Long COVID patients were at increased risk of thromboembolic disorders during 12 months of follow-up (HR: 2.648, 95% CI: 2.443-2.870) (83). In addition, increasing evidence demonstrates that venous thrombosis occurs more frequently than arterial thrombosis. A multicenter cohort study of 48 million people from England and Wales demonstrated a persistently elevated risk of venous thrombosis compared with arterial thrombosis 27-49 weeks after COVID-19 diagnosis (HR: 1.80, 95% CI: 1.50-2.17 vs. HR: 1.34, 95% CI: 1.21-1.48) (84). In conclusion, Long COVID is closely associated with thrombosis, imposing a substantial burden on healthcare systems. Therefore, further surveillance of D-dimer and early prophylactic anticoagulation are essential for patients at high risk of thrombotic events.
Caption The cardiovascular manifestations of Long COVID. Long COVID patients commonly manifest cardiovascular involvement, including myocarditis, ischemic and non-ischemic heart disease, arrhythmias, heart failure, and thrombotic events. Myocarditis is diagnosed by elevated high sensitivity troponin T (hsTnT) and abnormalities in electrocardiogram (ECG) and cardiac magnetic resonance imaging (CMR). Ischemic heart disease presents with coronary obstruction on computed tomographic angiography (CTA). Non-ischemic heart disease includes restrictive cardiomyopathy (RCM), dilated cardiomyopathy (DCM), and hypertrophic cardiomyopathy (HCM), which presents with ventricular hypertrophy, dilation, systolic and/or diastolic dysfunction on echocardiography. Arrhythmias are typically diagnosed by ECG abnormalities. The diagnosis of heart failure depends on laboratory and imaging abnormalities, including brain natriuretic peptide (BNP) > 100 pg/ml, N-terminal pro-BNP (NT pro-BNP) >300 pg/ml, and diastolic or systolic dysfunction on echocardiography. Thrombotic events are commonly diagnosed by elevated D-dimer levels (> 0.5 mg/L), detection of the thrombus on ultrasonography, and eccentric or mural filling defect on CTA. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1815269/full
“When [cancer] comes back, it comes back with a fury,” DeGregori said. “We think that these virus infections can be almost like fuel for the fire.” Unwelcome as COVID’s emergence was, the sheer scale of its spread has vastly deepened science’s understanding of the ways that viruses can continue to affect a human body long after the initial illness has passed. Scientists need a critical mass of data to be able to identify statistically significant patterns. In the case of a global pandemic “where the whole population gets infected, basically you have a denominator of 7 billion people,” said Dr. Stanley Perlman, a University of Iowa microbiologist who studies coronaviruses.
Mechanisms of Altered Immune Response in Skin Melanoma Radu-Florin Fruntealată et al. Curr Health Sci J. 2023 Jul-Sep. Show details Full text links Cite Abstract Melanoma, a deadly form of skin cancer, poses significant challenges to the host immune system, allowing tumor cells to evade immune surveillance and persist. This complex interplay between melanoma and the immune system involves a multitude of mechanisms that impair immune recognition and promote tumor progression. This review summarizes the intricate strategies employed by melanoma cells to evade the immune response, including defective immune recognition, immune checkpoint activation, and the role of regulatory T-cells, myeloid-derived suppressor cells, and exosomes in suppressing anti-tumor immunity. Additionally, we discuss potential therapeutic targets aimed at reversing immune evasion in melanoma, highlighting the importance of understanding these mechanisms for developing more effective immunotherapies. Improved insights into the interactions between melanoma and the immune system will aid in the development of novel treatment strategies to enhance anti-tumor immune responses and improve patient outcomes. Keywords: Melanoma; immune response; skin cancer. Curr Health Sci J. 2023 Sep 30;49(3):297–311. doi: 10.12865/CHSJ.49.03.01 Mechanisms of Altered Immune Response in Skin Melanoma RADU-FLORIN FRUNTEALATĂ 1, MATEI MARIUS 2, IANIS KEVYN STEFAN BOBOC 3, SMARANDA IOANA MITRAN 4, MARIUS EUGEN CIUREA 4, GEORGE-ALIN STOICA 6 https://pmc.ncbi.nlm.nih.gov/articles/PMC10832881/
Wiley Online Library Journal of Medical VirologyVolume 95, Issue 11 e29269 RESEARCH ARTICLE Open Access Molecular investigation of some DNA viruses in mucosal melanoma: Case–control study Rosaria Arvia, Michele Tanturli, Filippo Ugolini, Margherita Vannucchi, Daniela Massi, Krystyna Zakrzewska First published: 27 November 2023 https://doi.org/10.1002/jmv.29269Digital Object Identifier (DOI) view metrics Accessibility issue? Request accessibility update. PDF About Sections Abstract The association between viral infections and both cutaneous and mucosal melanoma (MM) has not been fully investigated. Here, we assessed the prevalence of the DNA of a broad range of viruses in 31 MMs and 15 biopsies of healthy mucosa (HM) using molecular methods. The parvoviruses CuV and B19V, herpesviruses HSV1, HSV2, EBV, HHV6, and HHV8, polyomavirus MCPyV, and α-HPVs were not detected, or rarely found, in MMs, and in HM, of the digestive, respiratory, and female genital tract. The overall prevalence of β-HPV in MMs was not significantly higher compared to that in HM (70.9% and 53.3% respectively; p = 0.514). However, the number of MMs positive for β-HPV types belonging to Species 3 and 5 and for some viral types belonging to Species 1, 2, 3, and 5 were significantly higher compared with HM (p < 0.05). Moreover, compared to HM, the MM samples contained a significantly higher number of β-HPV types, mainly belonging to Species 1, 3, and 5 (p < 0.05). Our data, although suggesting a role for certain β-HPV types in MM oncogenesis, require additional investigation in larger populations to support this hypothesis.