Jonathan Weissman Lab @weissmanlab.bsky.social · May 9 We engineered mESCs with the PEtracer system, which continuously installs heritable marks at >100 editable sites throughout development. Using these cells, we generated high-grade chimeric embryos (up to 99%) and reconstructed lineage trees resolving ~75% of cell divisions
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What did we find? We dissected fate restriction across the developing notochord, heart, neural crest, and tailbud. From these case studies, a few high-level principles about mammalian development emerged