Jacob Wolfe

@wolfepackscience.bsky.social

83 Followers 169 Following

Passionate About Peptide Chemistry, Enzyme Structure/Design, and Accessible Science 🧪 “Somewhere, something incredible is waiting to be known.” ― Carl Sagan #OpenToWork ChemImpex Next Big Thing in Science Fellow 2025 Graduate - Seth Horne's Lab @ Pitt 👨‍🔬

LinkedIn Article Title: Alpha Fold 3 Best Practices - How to Confidently Present an AF3 Structure (With Code!) The image is a two panel, on the left is a bar graph displaying triplicate mean and standard deviation values from 3 independent AlphaFold refolding simulations for the protein GB1, it's reversed sequence, and a scrambled sequence. On the right shows 4 ChimeraX visualizations of the models from that analysis. The original crystal structure 1PGA is color coded grey, other 3 models (GB1, Reversed, and Scramble) are color coded by Ca pLDDT scores. The reversed and scramble sequences have much lower scores.