William DeWitt @wsdewitt.github.io · May 20 We first checked that this works in a simulation (h/t stdpopsim). We used a challenging zigzag demography, and a mutation pulse. It seemed ok. (9/n)
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We next analyzed the new high-coverage 1000 Genomes data from NY Genome Center (26 human populations). We inferred a triplet mutation spectrum history for each population, and used non-negative tensor factorization to define a small vocabulary of mutation signatures. 5 =👍 (10/n)