William DeWitt @wsdewitt.github.io · May 20 From this decomposition we can do some projections to see that mutation histories cluster by population and by mutation type, with some spectrum components as outliers, indicating they’re doing something different over time, or over populations, or both. (11/n)
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We get mutation signatures that resemble cancer mutation signatures, but vary in dosage over each population’s history. We can ask new historical questions about mutagenic processes that are not possible to ask using mutation signature analysis on standing variation. (12/n)