Yash Gupta PhD

@yashul12.bsky.social

47 Followers 41 Following

🧬 Postdoc @PennStateMed | 🦠 Infectious Diseases | 💊 Drug Discovery | 🧫 Microbiome & RNA Therapeutics 📚 40+ Pubs | 🧪 Editor & Reviewer | 🌍 ORCID: 0000-0003-3002-1315 Bridging molecules & medicine. I chase cures with code, cells & curiosity. 🧬🧠

This study presents a novel biomimetic nanoparticle platform—Caco-2 cell membrane-coated, manganese-doped ZnO nanorods—for targeted microRNA (miR-200c-3p) delivery to intestinal epithelial cells. By combining magnetic responsiveness, homotypic targeting, and lipid membrane camouflage, the engineered nanoparticles achieve site-specific delivery, enhance intestinal permeability, and modulate tight junction integrity without inducing toxicity.

The work demonstrates, for the first time, that:

miRNA-loaded nanorods can be guided magnetically and penetrate the mucus barrier.
Homotypic targeting using epithelial cell membranes improves localization and uptake.
miR-200c delivery via this platform significantly alters occludin expression and gut permeability in vivo.
This approach opens new avenues for precision therapeutics in IBD and barrier dysfunction disorders, offering a biocompatible, traceable, and customizable delivery system for gut-targeted RNA therapies.